Results 141 to 150 of about 147,345 (227)

OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication

iMetaOmics, EarlyView.
Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu, Qiao Xue, Pengfei Liu, Zhihua Dong, Weijun Cao, Fan Yang, Yingming Zhu, Lei Deng, Zixiang Zhu, Haixue Zheng   +9 more
wiley   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Lineage Dynamics and Risk Factors Underlying Serotype 4 Invasive Pneumococcal Disease in Spain. [PDF]

J Infect Dis
Pérez-García C, Llorente J, Aguirre Alastuey ME, Llamosí M, Gil-Prieto R, Laghlali G, El-Ayache F, Yan V, Schotsaert M, Del Diego-Salas J, Cisneros JM, García-Sastre A, Domenech M, Sempere J, Yuste J.   +14 more
europepmc   +1 more source

Distribution chez la souris gestante du transgène GFP introduit avec un virus adéno-associé du sérotype 9

, 2018
La thérapie génique utilisant les vecteurs viraux est une des approches thérapeutiques possible pour le développement d’une thérapie pour les maladies génétiques mono-géniques dont l’ataxie de Friedreich (FRDA).
Kelu, Ken Bisabu
core  

Is Geenius HCV Supplemental Assay an Alternative to HCV Confirmatory Western Blot INNO‐LIA HCV Score in Repeatedly Reactive Blood Donations After First Line Screening?

Journal of Clinical Laboratory Analysis, EarlyView.
Serological testing of low prevalent blood donors: serological windows and false‐reactive screening results. There is moderate agreement between rapid immunochromatography test and western blot detecting anti‐HCV antibodies in blood donor sera. Discrepancies in results of immunochromatography test and western blot detecting anti‐HCV antibodies occur in
Zorana P. Kozić, Irina S. Maslovarić, Ivana T. Drvenica, Marijana V. Kovačić, Dragana C. Marković, Vesna Lj. Ilić, Dušan D. Vučetić   +6 more
wiley   +1 more source

Post-COVID Rebound in Invasive Pneumococcal Disease Driven by Resurgence of Serotype 4 Among American Indian Individuals in the Southwest United States. [PDF]

J Infect Dis
Sutcliffe CG, Sergent VM, Yazzie D, Brasinikas G, Christensen L, Clark M, Cowboy W, Dixon SL, Grant LR, Harker-Jones M, Hurley C, Iralu JV, McAuley JB, Miernyk K, Montanez P, Rice A, Romancito E, Salabye C, Simons-Petrusa B, Pitalua J, Tenequer VL, Thompson P, Tsingine M, VanDeRiet D, Weatherholtz RC, Santosham M, Hammitt LL.   +26 more
europepmc   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Association Between Pre-Existing Anti-Diphtheria Toxoid IgG and Immune Responses to a CRM₁₉₇-Conjugated 14-Valent Pneumococcal Conjugate Vaccine in Infants: A Post Hoc Analysis of a Multicenter Phase III Trial. [PDF]

Vaccines (Basel)
Thuluva S, Gunneri S, Ningaiah S, Yerroju V, Mogulla RR, Thammireddy K, Desai S, Gundu V, Jindal A, Nanjappa P, Chakravarthy BS, Mahantashetti NS, Verma S, Narang M, Prabhakar JP.   +14 more
europepmc   +1 more source

Absence of progressive liver disease after treatment in children with chronic hepatitis C: A nationwide registry study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives In adults with chronic hepatitis C (CHC) and advanced fibrosis, hepatocellular carcinoma (HCC) surveillance is recommended after achieving a sustained virologic response (SVR). However, post‐SVR surveillance strategies for children remain unclear. The aim of this study was to assess the durability of SVR and determine an appropriate
Hitoshi Tajiri, Mitsuyoshi Suzuki, Yuri Etani, Yoshinori Ito, Koichi Ito, Tomoya Fukuoka, Tatsuki Mizuochi   +6 more
wiley   +1 more source