Results 141 to 150 of about 141,120 (242)

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

The need for balanced dengue vaccine protection: Insights from Thai surveillance data on four serotypes. [PDF]

PLoS Negl Trop Dis
Khosavanna RR, Iamsirithaworn S, Pinpaiboon S, Phutthasophit K, Hunsawong T, Ko AI, Anderson KB, Buddhari D.   +7 more
europepmc   +1 more source

Effets de bactériocines sur le pathogène porcin "Streptococcus suis"

, 2014
Le but de cette étude était d’évaluer le potentiel antimicrobien de bactériocines pour le contrôle du pathogène porcin Streptococcus suis sérotype 2. Pour répondre au premier objectif de ce projet, la susceptibilité de S.
LeBel, Geneviève
core  

Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja, Savita Rangarajan, Will Lester, Bella Madan, Glenn F. Pierce, Emily Symington, Carolyn Millar, Dane Osmond, Mingjin Li, Konstantia‐Maria Chavele   +9 more
wiley   +1 more source

Invasive Pneumococcal Disease burden, clinical characteristics, serotypes' distribution, immunization status and antimicrobial resistance: Evidence from 12-year hospital-based surveillance and cost analysis. [PDF]

Hum Vaccin Immunother
Vecchio R, Iskandar E, Gentile L, Bertuccio P, Daprai L, Cambieri P, Muzzi A, Deandrea S, Riboli S, Cecconami L, Cereda D, Baldanti F, Odone A.   +12 more
europepmc   +1 more source

Will Extended‐Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At‐Risk Children?

Acta Paediatrica, EarlyView.
Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, IPD Study Group, Emmanuelle Varon   +8 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Distribution of <i>Streptococcus pneumoniae</i> Serotypes in Nasopharyngeal Carriage Among Children in Indonesia and Estimated Coverage of Pneumococcal Conjugate Vaccines: A Systematic Review. [PDF]

Vaccines (Basel)
Prayitno A, Karyanti MR, Putri ND, Wicaksana P, Felicia F, Ninditya S, Kemalasari S, Ardine A, Satari HI, Hadinegoro SR.   +9 more
europepmc   +1 more source

Surveillance épidémiologique des infections invasives à Haemophilus influenzae – 2024

Messages-clés Les infections invasives à Haemophilus influenzae de type b (Hib) sont en nette régression depuis l’introduction de la vaccination anti-Hib généralisée en 1993.
H. Theeten, P. Carrillo, C. Boulouffe, S. Jacquinet, A. Taame, B. Prevost, D. Martini, N. Hammami   +7 more
core  

Modélisation de la propagation, de la persistance et du contrôle des arbovirus dans le temps et dans l'espace : application au sérotype 8 du virus de la fièvre catarrhale ovine en population bovine

, 2012
Les arbovirus sont responsables de nombreuses maladies à transmission vectorielle majeures en santé publique et animale. Leurs vecteurs sont présents sur l’ensemble du globe.
Charron, Maud
core