Results 41 to 50 of about 5,029 (162)

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)

Frontiers in Oncology, 2019
Cancer testis (CT) antigens, under normal circumstances are uniquely expressed in testicular germ cells. Recent research has shown that meiosis-specific CT (meiCT) antigens are ectopically expressed in cutaneous T-cell lymphoma (CTCL) and may contribute ...
Jennifer Gantchev, Amelia Martínez Villarreal, Pingxing Xie, Philippe Lefrançois, Scott Gunn, Elena Netchiporouk, Denis Sasseville, Ivan V. Litvinov   +7 more
doaj   +1 more source

Diagnosis and Classification of Primary Nodal Lymphomas in Dogs: A Consensus of the Oncology‐Pathology Working Group

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT One of the primary objectives of the Oncology Pathology Working Group (OPWG) is for oncologists and pathologists to collaboratively generate consensus documents to standardise aspects of and provide guidelines for oncologic pathology in veterinary species.
Michael O. Childress, Anne Avery, Erica Behling‐Kelly, Peter Bennett, Laura Brockley, Ryan Dickinson, Kelly Hughes, William C. Kisseberth, Laura Marconato, Valeria Martini, Angela McCleary‐Wheeler, Lucia Minoli, Peter Rowland, Shane Sills, Luca Aresu   +14 more
wiley   +1 more source

Transient Leukemia in an Adult Dog With Cutaneous T‐Cell Lymphoma

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 5‐year‐old neutered female Beagle was presented with lethargy, vomiting, and reduced appetite. Physical examination revealed mild hyperthermia and a cutaneous thickness on the right thigh. Hematology showed marked leukocytosis and moderate thrombocytopenia, consisting of 80% of atypical circulating cells, initially suggesting acute ...
Raquel Moreira, Malgorzata Ossowska, Oriol Jornet‐Rius, Marta Santos, Francesco Cian   +4 more
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation Using Posttransplant Cyclophosphamide for Sézary Syndrome

Case Reports in Oncology, 2020
Patients with advanced-stage mycosis fungoides (MF) and Sézary syndrome (SS) have a poor prognosis. Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment option; however, since most patients with MF/SS are elderly, they ...
Madoka Kanda-Kato, Satoshi Yoshioka, Takayuki Ishikawa   +2 more
doaj   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome

Haematologica, 2007
This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation.
Evelyne Callet-Bauchu, Gilles Salles, Sophie Gazzo, Stéphane Dalle, Françoise Berger, Sandrine Hayette   +5 more
doaj   +1 more source

CD70: An emerging target for integrated cancer diagnosis and therapy

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
CD70 is aberrantly overexpressed in diverse tumours with limited normal tissue expression, making it a compelling diagnostic and therapeutic target. Immuno‐PET/CT facilitates tumour detection, staging, and treatment monitoring. Multiple CD70‐targeted therapies are under early evaluation. Rational combination strategies are emerging to enhance antitumor
Jiatao Hu, Jinxin Li, Bo Yang, Siyi Wang, Yi Bao, Yiren Yang, Kun Qiao, Fei Guo, Xinxin Gan, Linhui Wang   +9 more
wiley   +1 more source

Diffuse plane xanthomas as the first manifestation of multiple myeloma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Eleni Koutra, Elke Lusmöller, Hosam Ghanem, Astrid Aumann, Jens Atzpodien, Rudolf Stadler   +5 more
wiley   +1 more source

How to treat primary cutaneous B cell lymphoma – Results from a monocentric cohort study on 98 patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 7, Page 822-830, July 2025.
Summary Background Primary cutaneous B cell lymphomas (CBCL) are chronic diseases with frequent relapses. Time to next treatment (TTNT) is an endpoint reflecting clinical benefit of treatments including patient perspectives. The objectives were to evaluate clinical characteristics, survival, prognosis and TTNT in CBCL.
Rohat Cankaya, Pit Leonard Kleiner, Franz Joachim Hilke, Rose Moritz, Thomas Eigentler, Max Schlaak, Gabor Dobos   +6 more
wiley   +1 more source