Results 201 to 210 of about 15,844,621 (256)
Characterization of C3' Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin δ 2 Catalyzed by the Radical S-Adenosylmethionine Enzyme AbmJ. [PDF]
ACS CatalZhao H, Chen Z, Franklin JL, Liu HW.
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Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine. [PDF]
G3 (Bethesda)Remines M +9 more
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S-Adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes [PDF]
Journal of Hepatology, 2001 Background/Aims: Hepatocellular availability of S-adenosylmethionine, the principal biological methyl donor, is compromised in situations of liver damage.
Matias A Avila +2 more
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The International Journal of Biochemistry & Cell Biology, 2000
S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and polyamine synthesis. In transmethylation reactions, the methyl group of SAM is donated to a large variety of acceptor substrates including DNA, phospholipids and proteins ...
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S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and polyamine synthesis. In transmethylation reactions, the methyl group of SAM is donated to a large variety of acceptor substrates including DNA, phospholipids and proteins ...
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S-Adenosylmethionine radical enzymes
Bioorganic Chemistry, 2004The role of S-adenosylmethionine (SAM) as a precursor to organic radicals, generated by one-electron reduction of SAM and subsequent fission to form 5'-deoxyadenosyl radical and methionine, has been known for some time. Only recently, however, has it become apparent how widespread such enzymes are, and what a wide range of chemical reactions they ...
E Neil G, Marsh +2 more
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S-adenosylmethionine and affective disorder
The American Journal of Medicine, 1987Several open and double-blind studies suggest that SAMe may have an anti-depressant effect, and further studies are indicated. SAMe may exert a beneficial effect selectively on endogenous rather than neurotic depression. SAMe crosses the blood-brain barrier. SAMe is involved in several central enzyme pathways relating to transmethylation and folate and
M W, Carney, B K, Toone, E H, Reynolds
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S-Adenosylmethionine in the treatment of depression
Neuroscience & Biobehavioral Reviews, 1988The antidepressant property of S-adenosylmethionine (SAMe) has been supported by several uncontrolled and controlled studies. Compared to standard antidepressant agents, SAMe has fewer side-effects and shorter lag period. Future studies to delineate SAMe-responsive depression are warranted.
S A, Vahora, P, Malek-Ahmadi
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The synthesis of S-adenosylmethionine by mutants with defects in S-adenosylmethionine synthetase
Molecular and General Genetics MGG, 1976Some metK mutants of Salmonella typhimurium with constitutive methionine biosynthesis have no detectable S-adenosylmethionine (SAM) synthetase, the enzyme which converts methionine to SAM, the postulated corepressor of the methionine pathway. However, these mutants are not auxotrophic for SAM, an essential compound for many reactions.
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Inhibition of angiogenesis by S-adenosylmethionine
Biochemical and Biophysical Research Communications, 2011Metastasis is a leading cause of mortality and morbidity in cancer. One of the steps in metastasis process is the formation of new blood vessels. Aberrant DNA methylation patterns are common in cancer cells. In recent studies, S-adenosylmethionine (SAM), which is a DNA methylating agent, has been found to have inhibitory effects on some carcinoma cells
Mehmet, Sahin +4 more
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S-adenosylmethionine and its products
Amino Acids, 2007S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated
M A, Grillo, S, Colombatto
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