Results 211 to 220 of about 15,844,621 (256)

On Lowering S-Adenosylmethionine

1978
L-Dopa produces a marked lowering of brain S-adenosylmethionine (8), but nicotinamide, although also a methyl group acceptor, does not (3). It would be interesting to have a theoretical explanation for this difference in activity, especially if it would help in the selection of new agents which might have S-adenosylmethionine lowering activity.
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S-Adenosylmethionine and protein methylation

Amino Acids, 2005
The enzymes responsible for protein methylation by S-adenosylmethionine, both at the carboxyl groups and at the nitrogen groups, are reviewed. The possibility that the reactions involved may be reversible is also considered.
M A, Grillo, S, Colombatto
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SAMe: S-Adenosylmethionine

American Journal of Health-System Pharmacy, 2000
J C, Echols, U, Naidoo, C, Salzman
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine

Journal of Medicinal Chemistry, 1976
Structural analogues of S-adenosyl-L-methionine (SAM), with modifications in the amino acid, sugar, or base portions of the molecule, have been synthesized and evaluated as either inhibitors and/or substrates for the enzymes catechol O-methyltransferase, phenylethanolamine N-methyltransferase, histamine N-methyltransferase, and hydroxyindole O ...
R T, Borchardt, Y, Shiong, J A, Huber, A F, Wycpalek   +3 more
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Chiral instability at sulfur of S-adenosylmethionine

Biochemistry, 1983
S-Adenosylmethionine, generated enzymically in chirally pure form (S configuration at sulfur), undergoes simultaneous irreversible conversion to 5'-deoxy-5'-(methylthio)adenosine and homoserine with a rate constant of 6 X 10(-6) s-1 at pH 7.5 and 37 degrees C and reversible conversion to an enzymically inactive stereoisomer (R configuration at sulfur ...
S E, Wu, W P, Huskey, R T, Borchardt, R L, Schowen   +3 more
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S-adenosylmethionine decarboxylase as target of chemotherapy

Advances in Enzyme Regulation, 1985
Although ornithine decarboxylase under most conditions is the rate-controlling enzyme of polyamine biosynthesis and thus the most logical target for chemical intervention, the inhibition of the enzyme triggers a series of compensatory reactions all aimed to circumvent the inhibition. These include secondary induction of adenosylmethionine decarboxylase,
J, Jänne, L, Alhonen-Hongisto, P, Nikula, H, Elo   +3 more
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Chemical methylation of phosphatidylethanolamine by S-adenosylmethionine

Biochemical and Biophysical Research Communications, 1985
The chemical methylation of phosphatidylethanolamine (PE) by S-adenosyl methionine (SAM) is most active when carried out at alkaline pH's. Phosphatidylmonomethylethanolamine (PMME) and phosphatidyldimethylethanolamine are less effective reactants. The PE present in the microsomal and myelin membrane can serve as an acceptor in this reaction. Thin layer
V S, Bansal, J N, Kanfer
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S-Adenosylmethionine and its sulfur metabolites

1987
Publisher Summary This chapter discusses the S-adenosylmethionine and its sulfur metabolites. Biological reactions in which S-adenosylmethionine (AdoMet) is the methyl donor are key processes in many diverse cellular functions, such as transmethylation, transsulfuration, and polyamine biosynthesis.
R K, Gordon, G A, Miura, T, Alonso, P K, Chiang   +3 more
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S-Adenosylmethionine and methylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1996
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells.
P K, Chiang, R K, Gordon, J, Tal, G C, Zeng, B P, Doctor, K, Pardhasaradhi, P P, McCann   +6 more
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S-adenosylmethionine and depression.

Australian family physician, 2002
Depression is one on the most common psychological problems encountered in medical practice. Conventional antidepressants, although effective, have many side effects and there is a need for effective medications with fewer side effects.To present all the available clinical evidence on the supplement, S-adenosylmethionine (SAMe) in the treatment of ...
Minh, Nguyen, Angel, Gregan
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