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Timing insights in losartan-induced pancreatitis: a clinical case report. [PDF]
Oxf Med Case ReportsKaranjit S +5 more
europepmc +1 more source
Massive Amlodipine Overdose Complicated by Multiorgan Failure and Cardiac Arrest: A Case Report. [PDF]
Clin Med Insights Case RepMengistie BT +6 more
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Chemical Engineering Journal, 2012
Abstract A synergistic effect of selective separation of (S)-amlodipine using the di(2-ethylhexyl)phosphoric acid (D2EHPA) with the tartaric acid derivatives, O,O′-dibenzoyl-(2S,3S)-tartaric acid ((+)-DBTA) was developed for the enantioseparation of racemic amlodipine. The extractants were diluted in 1-decanol with various proportions. The influences
Prakorn Ramakul +2 more
exaly +2 more sources
Abstract A synergistic effect of selective separation of (S)-amlodipine using the di(2-ethylhexyl)phosphoric acid (D2EHPA) with the tartaric acid derivatives, O,O′-dibenzoyl-(2S,3S)-tartaric acid ((+)-DBTA) was developed for the enantioseparation of racemic amlodipine. The extractants were diluted in 1-decanol with various proportions. The influences
Prakorn Ramakul +2 more
exaly +2 more sources
Chemical Engineering Journal, 2012
Abstract A hollow fiber supported liquid membrane (HFSLM) containing the chiral selector O , O ′-dibenzoyl-(2 S ,3 S )-tartaric acid ((+)-DBTA) was characterized for the enantioseparation of ( R , S )-amlodipine. The influence of various chemical parameters, including the concentration of feed and receiving phases, as well as the carrier ...
Natchanun Leepipatpiboon +2 more
exaly +2 more sources
Abstract A hollow fiber supported liquid membrane (HFSLM) containing the chiral selector O , O ′-dibenzoyl-(2 S ,3 S )-tartaric acid ((+)-DBTA) was characterized for the enantioseparation of ( R , S )-amlodipine. The influence of various chemical parameters, including the concentration of feed and receiving phases, as well as the carrier ...
Natchanun Leepipatpiboon +2 more
exaly +2 more sources
Pharmacokinetic behaviour of R-(+)- and S-(−)-amlodipine after single enantiomer administration
Journal of Chromatography B: Biomedical Sciences and Applications, 1997Amlodipine, 3-ethyl 5-methyl-2-[(2-aminoethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methy l-3,5-pyridinedicarboxylate, is a chiral calcium antagonist, currently on the market and in therapeutic use as a racemate. The pharmacokinetic behaviour of R-(+)- and S-(-)-amlodipine after single enantiomer administration to healthy male human volunteers ...
Lukša, J +4 more
openaire +6 more sources
858 THE EFFECTIVENESS OF S(-)-AMLODIPINE ON VASCULAR FUNCTION
Journal of Hypertension, 2012Objective:This study was designed to determine the effectiveness of S(-)-amlodipine on vascular function compared with racemic amlodipine in Chinese patients with mild to moderate hypertension.Methods:This was a multicenter, randomized, double-blind, placebo-controlled study with two parallel ...
Jizhen Guo, Yanchun Gong, Yan Li
openaire +1 more source
Journal of Chromatography B: Biomedical Sciences and Applications, 1997
Pharmacokinetic studies of optically pure compounds after single enantiomer administration are becoming increasingly important. The process of racemization in vivo can diminish all expected advantages of single enantiomer treatment. Amlodipine, one of the calcium channel blockers, currently used in therapy as a racemate, is one of such drugs under ...
Lukša, J +4 more
openaire +3 more sources
Pharmacokinetic studies of optically pure compounds after single enantiomer administration are becoming increasingly important. The process of racemization in vivo can diminish all expected advantages of single enantiomer treatment. Amlodipine, one of the calcium channel blockers, currently used in therapy as a racemate, is one of such drugs under ...
Lukša, J +4 more
openaire +3 more sources
Technology Development for the Synthesis of S-Amlodipine Nicotinate Drug Substance
Pharmaceutical Chemistry Journal, 2017Technology for the synthesis of S-amlodipine nicotinate drug substance was developed based on an acceptable method of effective separation of the amlodipine optical isomers. A literature review suggested that the most promising methods employed 2-propanol (pure or with small additions of cosolvents) as the main solvent. However, experiments showed that
G. A. Kim +5 more
openaire +1 more source
International Journal of Pharmaceutics, 2009
The objective of the present investigation was to develop and evaluate a drug-in-adhesive transdermal patch for S-amlodipine (S-AM) free base. Initial in vitro experiments were conducted to optimize the formulation parameters before transdermal delivery in rats.
Yinghua, Sun +6 more
openaire +2 more sources
The objective of the present investigation was to develop and evaluate a drug-in-adhesive transdermal patch for S-amlodipine (S-AM) free base. Initial in vitro experiments were conducted to optimize the formulation parameters before transdermal delivery in rats.
Yinghua, Sun +6 more
openaire +2 more sources