Hypertension, 2006 In 2002, my colleagues and I1 suggested that blockade of the renin-angiotensin system may prevent diabetes by promoting adipogenesis, thereby allowing redistribution of fat from dangerous visceral and ectopic fat deposits to less-dangerous subcutaneous depots.
europepmc +5 more sources
Telmisartan for treatment of Covid-19 patients: An open multicenter randomized clinical trial
EClinicalMedicine, 2021 Background: Angiotensin receptor blockers (ARBs), such as telmisartan, have been postulated to treat Covid-19-induced lung inflammation. Methods: This is a parallel-group, randomized, two-arm, open-label, adaptive, multicenter superiority trial with 1:1 ...
Ignacio Davolos +2 more
exaly +3 more sources
Single-Cell Transcriptomics Reveals Immune Modulation by Telmisartan in Colorectal Cancer [PDF]
CellsTelmisartan, an angiotensin II type 1 receptor blocker with established anti-inflammatory and antihypertensive properties, has been reported to inhibit tumor cell proliferation, yet its impact on the tumor immune microenvironment remains poorly ...
Jinxin Li +11 more
doaj +2 more sources
Telmisartan-based monotherapy and combination regimens for blood pressure control in adults with hypertension: a systematic review, meta-analysis, and GRADE assessment [PDF]
BMC Cardiovascular DisordersPurpose To evaluate the efficacy, safety, and certainty of evidence for telmisartan-based antihypertensive regimens in adults with hypertension. Methods This systematic review and meta-analysis followed PRISMA 2020. PubMed/MEDLINE, Scopus, Web of Science,
Baraah Abu Alsel +6 more
doaj +2 more sources
Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin. [PDF]
PLoS ONEBackgroundPatients with type 2 diabetes mellitus (T2DM) usually accompany with the occurrence of high blood pressure, necessitating a combination of treatments.
Xin Zhou +6 more
doaj +2 more sources
Targeting AT1 receptors with telmisartan protects SH-SY5Y cells from 6-OHDA induced Parkinsonian neurotoxicity [PDF]
Scientific ReportsParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by oxidative stress, neuroinflammation, and α-synuclein accumulation.
Omer Lutfi Gundogdu +8 more
doaj +2 more sources
Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Acrylamide (ACR) is an environmental contaminant and neurotoxin. Telmisartan is an AT1 blocker that has neuroprotective properties basically through its anti-oxidant effect.
Zahra Yazadanpanah +3 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Objective: Telmisartan is an angiotensin receptor blocker (ARB) that specifically blocks angiotensin II type-1 receptors (AT1R). Telmisartan has been proven to have antidiabetic effects via a variety of mechanisms, and it can be utilized in some diabetic
Ahmed Abd-Eltawab Tammam +13 more
doaj +1 more source
Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells. [PDF]
PLoS ONE, 2014 Telmisartan, an angiotensin II receptor type 1 blocker, is often used as an antihypertension drug, and it has also been characterized as a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand.
Naoko Koyama +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Podocytes damage and mesangial cells expansion are two important pathological manifestations of glomerular injury in early diabetes. Telmisartan, as an angiotensin type 1 (AT1) receptor inhibitor, could improve advanced glycation end (AGE) products or ...
Xin Wei +8 more
doaj +1 more source