Results 11 to 20 of about 9,019 (158)

Central blood pressure lowering effect of telmisartan‐rosuvastatin single‐pill combination in hypertensive patients combined with dyslipidemia: A pilot study

The Journal of Clinical Hypertension, 2021
This multicenter, phase 4, Prospective Randomized Open, Blinded End‐point (PROBE) study aimed to evaluate safety and efficacy of telmisartan/rosuvastatin single‐pill combination (SPC) therapy on lowering central blood pressure (BP) compared with ...
JungMin Choi, Ki‐Chul Sung, Sang‐Hyun Ihm, Chang‐Hwan Yoon, Seung Woo Park, Sung‐Ha Park, Jang‐Young Kim, Sung‐Uk Kwon, Hae‐Young Lee   +8 more
doaj   +1 more source

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak, Paramita Pattanayak, Tanmay Chatterjee, Balaram Ghosh, Mohamed Raafat, Mohammed A. S. Abourehab   +7 more
doaj   +1 more source

Antiproliferative and apoptotic effects of telmisartan in human glioma cells

Cancer Cell International, 2023
Glioblastoma is the most common primary central nervous system tumor in adults. Angiotensin II receptor blockers (ARBs) are broadly applied to treat hypertension.
Yung-Lung Chang, Chung-Hsing Chou, Yao-Feng Li, Li-Chun Huang, Ying Kao, Dueng-Yuan Hueng, Chia-Kuang Tsai   +6 more
doaj   +1 more source

Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver [PDF]

Yeungnam University Journal of Medicine, 2019
Background Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure ...
Kae Won Cho, Du-Hyong Cho
doaj   +1 more source

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

Cardiovascular Diabetology, 2012
Background Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a partial agonist
Shiota Asuka, Shimabukuro Michio, Fukuda Daiju, Soeki Takeshi, Sato Hiromi, Uematsu Etsuko, Hirata Yoichiro, Kurobe Hirotsugu, Maeda Norikazu, Sakaue Hiroshi, Masuzaki Hiroaki, Shimomura Iichiro, Sata Masataka   +12 more
doaj   +1 more source

Effects of antihypertensive agents on the quality of life in diabetic hypertensive patients: A prospective study

Perspectives in Clinical Research, 2022
Background: Diabetes mellitus is a chronic noncommunicable disease, and hypertension (HT) is the most common comorbidity which affects their quality of life (QoL).
Raj Kumar Bhardwaj, H L Kazal, Kamlesh Kohli, Rajnish Raj, Nagma Bansal, Baltej Singh, Hobinder Arora   +6 more
doaj   +1 more source

Telmisartan and cardioprotection

Vascular Health and Risk Management, 2011
Cardiovascular risk reduction has been the target of several large clinical trials in the last decade. As the activation of the renin-angiotensin-aldosterone system (RAAS) plays a central role in the pathogenesis of atherosclerosis and cardiovascular disease, RAAS blockade has been suggested to be among the most efficient cardioprotective interventions,
Akhrass,Philippe R, McFarlane,Samy I
openaire   +5 more sources

SARTANS OF THE SECOND GENERATION: THERAPEUTIC POTENTIAL EXTENSION

Рациональная фармакотерапия в кардиологии, 2016
Peculiarities of the treatment with angiotensin II receptor blocker telmisartan are analyzed taking into account its clinical and pharmacological characteristics. Special attention is paid to the telmisartan benefits in comparison with other sartans. Key
S. V. Nedogoda
doaj   +1 more source

Immune pleiotropic effect of telmisartan in arterial hypertension

Медицинская иммунология, 2022
Arterial hypertension (AH) is among the life-threatening diseases and requires permanent antihypertensive therapy, including telmisartan. However, the effect of telmisartan upon systemic interleukin profile in elderly hypertensive patients requires ...
N. M. Agarkov, K. F. Makkonen, A. A. Titov, D. N. Belchikova, L. V. Kolpina   +4 more
doaj   +1 more source

Telmisartan Treatment Ameliorates Memory Deficits in Streptozotocin-Induced Diabetic Mice via Attenuating Cerebral Amyloidosis

Journal of Pharmacological Sciences, 2014
Telmisartan, an angiotensin II type 1–receptor blocker (ARBs), has been reported to exert beneficial effects on the central nervous system (CNS). However, the effect of telmisartan on cognitive impairment associated with type 1 diabetes is not well known.
Guan Tao Du, Meng Hu, Zhen Lin Mei, Chao Wang, Guang Jun Liu, Mei Hu, Yan Long, Ming Xing Miao, Jia Chang Li, Hao Hong   +9 more
doaj   +1 more source