Results 21 to 30 of about 12,197 (188)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c-Mediated Epigenetic Silencing. [PDF]

Adv Sci (Weinh)
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Kan T, Li X, Wang H, Sun L, Wang Y, Wu J, Cui J, Yang Y, Yuan K, Chu L, Wang L, Li H, Yan M, Yu Z.   +13 more
europepmc   +2 more sources

Impact of Albuminuria-Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the ROTATE Trials. [PDF]

Diabetes Obes Metab
ABSTRACT Aim Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD.
Pigsborg K, Kienle SM, Wretlind A, Rotbain Curovic V, Blond MB, Heerspink HJL, Hansen TW, Persson F, Sulek K, Legido-Quigley C, Rossing P.   +10 more
europepmc   +2 more sources

YK-4-250, a synthetic telmisartan-tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT₁ receptor inhibitor. [PDF]

Acta Crystallogr C Struct Chem
The first crystal structure of the telmisartan–tempol conjugate YK‐4‐250 is reported, revealing the intramolecular C–H…π interactions that stabilize the nitroxide radical while preserving the angiotensin AT1 receptor antagonist pharmacophore.We report the first crystal structure of the telmisartan–tempol conjugate 2,2,6,6‐tetramethyl‐1‐(λ′‐oxidaneyl ...
Friedrich S, Kong Y, Musayev FN, Brown ML, Gupton BF.   +4 more
europepmc   +2 more sources

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post-Myocardial Infarction Therapy. [PDF]

Adv Sci (Weinh)
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Lu H, Deng K, Zhang Z, Wang Q, Gao W, Shen L, Zhang L, Hu W, Zhu Y, Mao Z, Ren T.   +10 more
europepmc   +2 more sources

Differential Molecular Interactions of Telmisartan: Molecular-Level Insights from Spectral and Computational Studies [PDF]

, 2022
In this study, we investigated differential molecular interactions of crystalline and amorphous forms of telmisartan (TEL), which is a non-peptide angiotensin-II receptor antagonist commonly used in the management of hypertension. Amorphous telmisartan (
Vasanthanathan , Poongavanam, Mahendra, Singh, N. Arul , Murugan, Jacob , Kongsted, Uttam Chand, Banerjee, Peng , Zhan   +5 more
core   +1 more source

Central blood pressure lowering effect of telmisartan‐rosuvastatin single‐pill combination in hypertensive patients combined with dyslipidemia: A pilot study

The Journal of Clinical Hypertension, 2021
This multicenter, phase 4, Prospective Randomized Open, Blinded End‐point (PROBE) study aimed to evaluate safety and efficacy of telmisartan/rosuvastatin single‐pill combination (SPC) therapy on lowering central blood pressure (BP) compared with ...
JungMin Choi, Ki‐Chul Sung, Sang‐Hyun Ihm, Chang‐Hwan Yoon, Seung Woo Park, Sung‐Ha Park, Jang‐Young Kim, Sung‐Uk Kwon, Hae‐Young Lee   +8 more
doaj   +1 more source

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak, Paramita Pattanayak, Tanmay Chatterjee, Balaram Ghosh, Mohamed Raafat, Mohammed A. S. Abourehab   +7 more
doaj   +1 more source

Exploring the effects of processing methods on telmisartan-phospholipid complex: A comparative study [PDF]

, 2022
Drug-phospholipid complexes have emerged as potential drug delivery systems for poorly soluble drugs. The purpose of this study was to investigate the effect of processing methods on the physicochemical and biopharmaceutical performance of the ...
Charan, Singh, Sarasija, Suresh, Uttam Chand, Banerjee, Mahendra, Singh, Sabyasachi, Roy   +4 more
core   +1 more source

Telmisartan Potentiates Insulin Secretion via Ion Channels, Independent of the AT1 Receptor and PPARγ

Frontiers in Pharmacology, 2021
Angiotensin II type 1 (AT1) receptor blockers (ARBs), as antihypertensive drugs, have drawn attention for their benefits to individuals with diabetes and prediabetes. However, the direct effects of ARBs on insulin secretion remain unclear. In this study,
Tao Liu, Tao Liu, Tao Liu, Lijuan Cui, Lijuan Cui, Huan Xue, Huan Xue, Xiaohua Yang, Mengmeng Liu, Linping Zhi, Huanhuan Yang, Zhihong Liu, Zhihong Liu, Min Zhang, Qing Guo, Peifeng He, Yunfeng Liu, Yi Zhang, Yi Zhang   +18 more
doaj   +1 more source

Antiproliferative and apoptotic effects of telmisartan in human glioma cells

Cancer Cell International, 2023
Glioblastoma is the most common primary central nervous system tumor in adults. Angiotensin II receptor blockers (ARBs) are broadly applied to treat hypertension.
Yung-Lung Chang, Chung-Hsing Chou, Yao-Feng Li, Li-Chun Huang, Ying Kao, Dueng-Yuan Hueng, Chia-Kuang Tsai   +6 more
doaj   +1 more source