Results 31 to 40 of about 12,197 (188)

MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells [PDF]

open access: yes, 2021
香川大学Kagawa University博士(医学)Background: Panereatic ductal adenocarcinoma (PDAC) is the most devastating of all cancers with an extremely poor prognosis. It has few effective and reliable therapeutic strategies.
Yamana, Yoshimi   +2 more
core   +2 more sources

Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes [PDF]

open access: yes, 2008
<b>Background:</b> Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs.
Fauvel, J.P.   +11 more
core   +2 more sources

Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver [PDF]

open access: yesYeungnam University Journal of Medicine, 2019
Background Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure ...
Kae Won Cho, Du-Hyong Cho
doaj   +1 more source

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

open access: yesCardiovascular Diabetology, 2012
Background Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a partial agonist
Shiota Asuka   +12 more
doaj   +1 more source

Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [C-11]Telmisartan [PDF]

open access: yes, 2022
The angiotensin receptor blocker telmisartan slows progression of kidney disease in patients with type 2 diabetes (T2D), yet many patients remain at high risk for progressive kidney function loss.
Slart, Riemer H. J. A.   +22 more
core   +2 more sources

SARTANS OF THE SECOND GENERATION: THERAPEUTIC POTENTIAL EXTENSION

open access: yesРациональная фармакотерапия в кардиологии, 2016
Peculiarities of the treatment with angiotensin II receptor blocker telmisartan are analyzed taking into account its clinical and pharmacological characteristics. Special attention is paid to the telmisartan benefits in comparison with other sartans. Key
S. V. Nedogoda
doaj   +1 more source

Telmisartan Exerts Anti-Tumor Effects by Activating Peroxisome Proliferator-Activated Receptor-γ in Human Lung Adenocarcinoma A549 Cells

open access: yesMolecules, 2014
Telmisartan, a member of the angiotensin II type 1 receptor blockers, is usually used for cardiovascular diseases. Recent studies have showed that telmisartan has the property of PPARγ activation.
Juan Li   +5 more
doaj   +1 more source

Effects of antihypertensive agents on the quality of life in diabetic hypertensive patients: A prospective study

open access: yesPerspectives in Clinical Research, 2022
Background: Diabetes mellitus is a chronic noncommunicable disease, and hypertension (HT) is the most common comorbidity which affects their quality of life (QoL).
Raj Kumar Bhardwaj   +6 more
doaj   +1 more source

Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly [PDF]

open access: yes, 2010
Bodh I JugduttDivision of Cardiology, Department of Medicine, University of Alberta and Hospital, Edmonton, CanadaAbstract: Elderly patients (age≥65 years) with hypertension are at high risk for vascular complications, especially when diabetes is ...
Bodh I Jugdutt, Bodh Jugdutt
core   +1 more source

Telmisartan Treatment Ameliorates Memory Deficits in Streptozotocin-Induced Diabetic Mice via Attenuating Cerebral Amyloidosis

open access: yesJournal of Pharmacological Sciences, 2014
Telmisartan, an angiotensin II type 1–receptor blocker (ARBs), has been reported to exert beneficial effects on the central nervous system (CNS). However, the effect of telmisartan on cognitive impairment associated with type 1 diabetes is not well known.
Guan Tao Du   +9 more
doaj   +1 more source

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