Results 51 to 60 of about 9,019 (158)

Tirzepatide‐Induced Functional Small Bowel Obstruction in a Surgically Naïve Patient: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Tirzepatide dose escalation may precipitate functional small bowel obstruction that mimics mechanical obstruction, even in surgically naïve patients. Careful medication review and objective tools such as the water‐soluble contrast challenge can support safe non‐operative management and help avoid unnecessary surgical intervention.
Takuto Shimada   +4 more
wiley   +1 more source

Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. [PDF]

open access: yesPLoS ONE, 2013
Human autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital hepatic fibrosis characterized by dilated bile ducts and portal hypertension.
Daisuke Yoshihara   +8 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

open access: yesCancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang   +4 more
wiley   +1 more source

Telmisartan Self-Nanoemulsifying Drug Delivery System, Compared With Standard Telmisartan, More Effectively Improves Hepatic Fibrosis in Rats

open access: yesDose-Response, 2020
Background: This study was designed to examine effects of telmisartan; an angiotensin receptor blocker; self-nanoemulsifying drug delivery system (SNEDDS) in reversing already-established hepatic fibrosis. Method: Forty rats were given thioacetamide (200
Hussam Murad   +3 more
doaj   +1 more source

Valsartan Reduces Myocardial Ischemia–Reperfusion Injury by Inhibiting Ferritinophagy‐Mediated Ferroptosis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Revascularisation is the key therapeutic strategy for acute myocardial infarction (AMI). However, the opening of the ‘culprit artery’ is accompanied by myocardial ischemia–reperfusion injury (IRI), partially offsetting the benefits of revascularisation. At present, effective methods to alleviate myocardial IRI are lacking.
Xumin Wang   +8 more
wiley   +1 more source

Clinicopathological Features and Postoperative Complication Management of a Postauricular Granular Cell Tumor: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Postauricular granular cell tumors mimic parotid malignancies. Their resection disrupts fragile local microcirculation due to inherently thin skin and limited subcutaneous buffer, triggering ischemic necrosis and MRSE infection. Clinicians must prioritize functional tissue preservation and vigilant wound care to prevent these severe ...
Haotong Yuan   +4 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu   +5 more
wiley   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes   +4 more
wiley   +1 more source

The vasodilatory action of telmisartan on isolated mesenteric artery rings from rats [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2015
Objective(s): Angiotensin Ⅱ type 1 receptor blockers (ARBs) represent one of the widely used antihypertensive agents. In addition to anti-hypertension effect, some ARBs also show other molecular effects such as activating peroxisome proliferator ...
Xiao-ping Chen, Li-ren Qian
doaj  

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