Results 91 to 100 of about 28,447,240 (259)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Warped AdS6 × S 2 in Type IIB supergravity II: global solutions and five-brane webs
Journal of High Energy Physics, 2017 Motivated by the construction of holographic duals to five-dimensional superconformal quantum field theories, we obtain global solutions to Type IIB supergravity invariant under the superalgebra F (4) on a space-time of the form AdS6 × S 2 warped over a ...
Eric D’Hoker +2 more
doaj +1 more source
Norwegian mutual fund performance based on Fama and French´s five-factor model
, 2016 The following paper uses a dataset free of survivorship bias for the period 2002-2011. We investigate whether Norwegian mutual funds possess enough skills to outperform a passive benchmark based on Fama and French’s five-factor model. Our results suggest that the mutual fund industry exhibits significant excess returns on a 10% level in the recent ...
Mustafa, Daniel Amir +1 more
openaire +1 more source
Studi Francesi, 2004 C. E. analyse d’abord rapidement la tradition manuscrite du «Banquet du Faisan», qui comprend: la version contenue dans les Memoires d’Olivier de La Marche, celle de la Chronique de Mathieu d’Escouchy, celles des manuscrits Paris BnF fr. 11594, Paris BnF fr. 5739, Bruxelles BR IV.1103.
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Littera Scripta, 2019 One of the important factors for successful management is the knowledge of the competitive environment in which the business operates and the ability to adequately respond to changes.
Olga Kutnohorská, Jana Krištůfková
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Minimizing the Risk of Wrong-site Dermatologic Surgery: The Five “I”s Process
Plastic and Reconstructive Surgery, Global Open, 2023 Elizabeth Rajiah, MRCS (Eng) +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source