Results 111 to 120 of about 28,447,240 (259)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The Five C’s: Bringing a 1980’s Film into the 21st Century Chinese Language Learning Context
L2 Journal, 2011 Film has become an ever more effective medium of instruction in foreign languages, including Chinese. Developing good textbooks to accompany the films is too labor-intensive to keep pace with the growing production of contemporary films, so it is useful ...
Gloria Bien
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Analyzing the Dental Market Through Porter�s Five Forces Framework
Annali di StomatologiaThis commentary explores the dental healthcare market through the lens of Porter’s Five Forces, a model for analyzing the competitive environment of a market. By applying this framework, it is possible to elucidate the market dynamics affecting dentists, dental specialists, and patients, providing insights into the consequences and challenges faced by ...
Alessandro Quaranta, Wang Lai Hui
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Nevanlinna's five-value theorem for algebroid functions [PDF]
Ufimskii Matematicheskii Zhurnal, 2018 openaire +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Reproductive contributions of Taiwan's foreign wives from the top five source countries
Demographic Research, 2011 This research studies the reproductive contributions of Taiwan's foreign wives from China, Vietnam, Indonesia, Thailand, and the Philippines, based on applications of the multinomial logit model to the micro data of the 2003 Census of Foreign ...
Kao-Lee Liaw +2 more
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