Results 81 to 90 of about 21,171,580 (198)

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science
Nitric oxide (NO), a pivotal redox signaling molecule, coordinates plant development and immune responses through S‐nitrosylation‐mediated protein modification. While NO‐dependent S‐nitrosylation fine‐tunes immune responses, whether pathogens hijack this
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
doaj   +1 more source

Nitric Oxide‐Releasing Catheters with Phenol‐Amine Catalytic Coatings for Improved Anti‐Inflammatory Performance

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
Tannic acid‐selenocystamine (TA‐SeCA) nanocoating enables stable, sustained catalytic nitric oxide (NO) release on catheter surfaces. This one‐step phenol‐amine coating improves catheter functionality by enhancing endogenous NO production, supporting vascular function, and reducing inflammation.
Qingqing Fan, Shu Geng, Tanveer A. Tabish, Kang Lin, Yiyi Yin, Siti Nur Asyura Adzlan, Federico Mazur, Rona Chandrawati   +7 more
wiley   +1 more source

Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

Pharmaceutics, 2020
Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing.
Jiafu Cao, Mingzhi Su, Nurhasni Hasan, Juho Lee, Dongmin Kwak, Dong Young Kim, Keonwoo Kim, Eun Hee Lee, Jee H. Jung, Jin-Wook Yoo   +9 more
doaj   +1 more source

Pre-exercise nitric oxide donor supplementation attenuates decline in muscle contractile force and ryanodine receptor proteolysis following eccentric contraction

Journal of Physical Fitness and Sports Medicine
The aim of this study was to elucidate the effects of oral administration of S-nitrosoglutathione (GSNO), a nitric oxide donor, on force production and Ca2+ regulatory proteins in fast-twitch muscles subjected to eccentric contraction (ECC).
Satoshi Matsunaga, Daiki Watanabe, Keita Kanzaki, Sumiko Matsunaga-Futatsuki, Masanobu Wada   +4 more
doaj   +1 more source

Increased Nitrosoglutathione Reductase Activity in Hypoxic Pulmonary Hypertension in Mice

Journal of Pharmacological Sciences, 2010
Altered S-nitrosothiols (RSNO) signaling is linked to pulmonary hypertension. Recent studies have shown that S-nitrosoglutathione (GSNO) reductase (GSNOR) catalyzes the degradation of GSNO and indirectly regulates the level of RSNO in vivo.
Xiling Wu, Lizhong Du, Xuefeng Xu, Linhua Tan, Ruyi Li   +4 more
doaj   +1 more source

GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation

Redox Biology, 2018
The adaptive immune system plays a critical role in hyperhomocysteinemia (HHcy)-accelerated atherosclerosis. Recent studies suggest that HHcy aggravates atherosclerosis with elevated oxidative stress and reduced S-nitrosylation level of redox-sensitive ...
Jing Li, Yan Zhang, Yuying Zhang, Silin Lü, Yutong Miao, Juan Yang, Shenming Huang, Xiaolong Ma, Lulu Han, Jiacheng Deng, Fangfang Fan, Bo Liu, Yong Huo, Qingbo Xu, Chang Chen, Xian Wang, Juan Feng   +16 more
doaj   +1 more source

S-nitrosation of conserved cysteines modulates activity and stability of S-nitrosoglutathione reductase (GSNOR)

Biochemistry, 2016
The free radical nitric oxide (NO•) regulates diverse physiological processes from vasodilation in humans to gas exchange in plants. S-nitrosoglutathione (GSNO) is considered a principal nitroso reservoir due to its chemical stability.
Damian D. Guerra, Keith N. Ballard, Ian Truebridge, E. Vierling   +3 more
semanticscholar   +1 more source

Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor

Journal of Cardiovascular Pharmacology and Therapeutics, 2016
Background and Purpose: Published data on nebivolol reveal selective β1 adrenergic selectively along with novel nitric oxide (NO)-dependent vasodilatory properties. However, the exact molecular mechanism is unknown.
Hong, Jiang, David J, Polhemus, Kazi N, Islam, Ashley C, Torregrossa, Zhen, Li, Amy, Potts, David J, Lefer, Nathan S, Bryan   +7 more
openaire   +2 more sources

Metal−Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S‑Nitrosoglutathione in Aqueous Solution

ACS Applied Materials and Interfaces, 2017
It has been previously demonstrated that copper-based metal−organic frameworks (MOFs) accelerate formation of the therapeutically active molecule nitric oxide (NO) from S-nitrosothiols (RSNOs).
M. Neufeld, A. Lutzke, Jesuś B. Tapia, Melissa M. Reynolds   +3 more
semanticscholar   +1 more source

Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study.

Nitric oxide, 2019
Nitric oxide (NO) is a crucial molecule in the human body. The encapsulation of exogenous NO donors into chitosan nanoparticles (CS NPs) has been widely used to overcome NO drawbacks in pharmacological applications, such as, its short half-life.
M. T. Pelegrino, R. Weller, A. Paganotti, A. Seabra   +3 more
semanticscholar   +1 more source