Results 111 to 120 of about 1,430,925 (278)

Optimizing the Fractional Power in a Model with Stochastic PDE Constraints

Advanced Nonlinear Studies, 2018
We study an optimization problem with SPDE constraints, which has the peculiarity that the control parameter s is the s-th power of the diffusion operator in the state equation.
Geldhauser Carina, Valdinoci Enrico
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Exploration of skewness parameter of Skew-Cosh-Gaussian laser beam propagating through collisionless plasma

Results in Optics
The skewness parameter ‘s’ of a skew-cosh-Gaussian (skew-chG) laser beam travelling through collisionless plasma was analytically investigated in the current theoretically study.
K.Y. Khandale, S.D. Patil, M.V. Takale
doaj   +1 more source

A vertex-structure model for new direct CP-violating effects in Bbar^0(B^0) -> phi K_S and in B^-+ -> pi^-+ eta' (eta)

, 2006
We consider effective Lagrangian models of CP-violating vertex structure in which a $b -> uW$ vertex, proportional to $s_{13}e^{-i\delta_{13}}$ with $s_{13}$ very small (milliweak interaction) and $\delta_{13}$ large, is dynamically generated.
Barshay, Saul, Kreyerhoff, Georg
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fatigue life prediction method based on data fusion

Journal of Aeronautical Materials
To address the challenges posed by the time-consuming nature of fatigue test and the scattered nature of test data，it is evident that P-S-N curves derived from small samples with high survival rates lack sufficient accuracy，leading to unreliable ...
ZHANG Xu, YAO Jianyao, LIU Xuyang, WANG Changyin, GAO Youzhi   +4 more
doaj   +1 more source

Combined Constraints on Holographic Bosonic Technicolor

, 2010
We consider a model of strong electroweak symmetry breaking in which the expectation value of an additional, possibly composite, scalar field is responsible for the generation of fermion masses.
Christopher D. Carone, E. Witten, J. F. Gunion, J. M. Maldacena, Reinard Primulando, X. L. Wang, Y. G. Cao   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

S-parameter and vector decay constant in QCD with eight fundamental fermions

, 2015
SU(3) gauge theory with eight massless fundamental fermions seems to be near the conformal boundary, and is a candidate theory of walking technicolor.
Aoki, Yasumichi, Aoyama, Tatsumi, Bennett, Ed, Kurachi, Masafumi, LatKMI collaboration, Maskawa, Toshihide, Miura, Kohtaroh, Nagai, Kei-ichi, Ohki, Hiroshi, Rinaldi, Enrico, Shibata, Akihiro, Yamawaki, Koichi, Yamazaki, Takeshi   +12 more
core   +1 more source