Results 101 to 110 of about 30,414,319 (280)

Diophantine conditions in global well-posedness for coupled KdV-type systems

Electronic Journal of Differential Equations, 2009
We consider the global well-posedness problem of a one-parameter family of coupled KdV-type systems both in the periodic and non-periodic setting. When the coupling parameter $alpha = 1$, we prove the global well-posedness in $H^s(mathbb{R}) $ for $s >
Tadahiro Oh
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Fatigue life prediction method based on data fusion

Journal of Aeronautical Materials
To address the challenges posed by the time-consuming nature of fatigue test and the scattered nature of test data，it is evident that P-S-N curves derived from small samples with high survival rates lack sufficient accuracy，leading to unreliable ...
ZHANG Xu, YAO Jianyao, LIU Xuyang, WANG Changyin, GAO Youzhi   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pulsating string solution and stability in two parameter χ-deformed background

Journal of High Energy Physics
In this paper, we investigate pulsating string solutions within the context of two parameter χ-deformed R $$ \mathcal{R} $$ × S 2 background. We derive the energy and oscillation number relation for the deformed R $$ \mathcal{R} $$ × S 2 in short string ...
Rashmi R Nayak, Nibedita Padhi, Manoranjan Samal   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Vector discrete problems: parametrization of an optimality principle and conditions of solvability in the class of algorithms involving linear convolution of criteria [PDF]

Computer Science Journal of Moldova, 2001
An n-criteria problem with a finite set of vector valuations is considered. An optimality principle of this problem is given by an integer-valued parameter s, which is varied from 1 to n-1.
V.A. Emelichev, A.V. Pashkevich
doaj