Results 81 to 90 of about 3,120,441 (282)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Estimation of Activity Interaction Parameters in Fe-S-j Systems

Entropy, 2018
It is important to know the activity interaction parameters between components in melts in the process of metallurgy. However, it’s considerably difficult to measure them experimentally, relying still to a large extent on theoretical calculations ...
Tianhua Ju, Xueyong Ding, Yingyi Zhang, Weiliang Chen, Xiangkui Cheng, Bo Wang, Jingxin Dai, Xinlin Yan   +7 more
doaj   +1 more source

Coplanar waveguide discontinuities for P-I-N diode switches and filter applications [PDF]

A full wave space domain integral equation (SDIE) analysis of coplanar waveguide (CPW) two port discontinuities is presented. An experimental setup to measure the S-parameters of such discontinuities is described. Experimental and theoretical results for
Dib, N. I., Katehi, P. B., Ponchak, George E., Simons, Rainee N.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

De-embedding method for a sensing area characterization of planar microstrip sensors without evaluating error networks

Scientific Reports
A de-embedding method for determining all scattering (S-) parameters (e.g., characterization) of a sensing area of planar microstrip sensors (two-port network or line) is proposed using measurements of S-parameters with no calibration.
Ugur C. Hasar, Hamdullah Ozturk, Huseyin Korkmaz, Vahid Nayyeri, Omar M. Ramahi   +4 more
doaj   +1 more source

Assessment of Performance of One-Turn Inductors in Series Configuration Through a Transmission-Line Modeling Approach

IEEE Access
In this paper, transmission-line theory is applied to implement a physical model for compact one-turn inductors, which simultaneously incorporates the frequency-dependent effects introduced by the conductor skin effect and the loss originated by the ...
German Alvarez-Botero, Eduardo Moctezuma-Pascual, Miguel A. G. Laso, Reydezel Torres-Torres   +3 more
doaj   +1 more source

Patient safety in Europe: medication errors and hospital-acquired infections [PDF]

, 2008
The Report was commissioned by the European Federation of Nurses Associations (EFN) in November 2007 in order to support its policy statements on Patient Safety (June 2004).
Burke, J., Smith, L.N., Sveinsdóttir, H., Willman, A.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Broadband S-Parameter-Based Characterization of Multilayer Ceramic Capacitors Submitted to Mechanical Stress Through Bending Tests on a PCB

Micromachines
A full characterization of multilayer ceramic capacitors including variations in capacitance, series resistance, and series inductance is accomplished by measuring their RF response while being submitted to mechanical stress.
Victoria Gutiérrez-Vicente, Jesús Alejandro Torres-Torres, Reydezel Torres-Torres   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source