Results 211 to 220 of about 303,306 (282)

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

open access: yesThe FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza   +4 more
wiley   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

open access: yesThe FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima   +12 more
wiley   +1 more source

Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. [PDF]

open access: yesJ Immunol, 2020
Adams W   +8 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

open access: yesImmunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude   +2 more
wiley   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li   +3 more
wiley   +1 more source

Microbiota and clinical outcomes of implant‐supported full‐mandible dentures on patients with a history of periodontitis: A 5‐year prospective cohort study

open access: yesJournal of Prosthodontics, EarlyView.
Abstract Purpose To characterize the microbiota of implant‐supported full‐mandible dentures and its correlation to clinical outcomes for up to 5 years after implant loading in patients with a history of periodontal disease. Materials and Methods Twelve individuals with a history of periodontitis (Stage IV and Grade B) received five immediate implants ...
Jefferson Antônio Gomes   +4 more
wiley   +1 more source

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