Results 71 to 80 of about 15,017 (189)

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Neutrophil Extracellular Traps Participate in the Pathogenesis of Lupus Through S100A10‐Mediated Regulatory T‐Cell Differentiation and Functional Abnormalities

European Journal of Immunology
In systemic lupus erythematosus (SLE), neutrophil dysregulation and neutrophil extracellular traps (NETs) formation contribute to disease pathogenesis, potentially worsening the autoimmune response.
Hua Guo, Qian Liang, Zhonghui Xue, Junling Yang, Pengyu Chen, Juan Ji, Jing Li, G. Guo, H. Cao, Xiaoqi Sha, Rui Zhao, C. Dong, Zhifeng Gu   +12 more
semanticscholar   +1 more source

S100A10 and Cancer Hallmarks: Structure, Functions, and its Emerging Role in Ovarian Cancer

, 2018
S100A10, which is also known as p11, is located in the plasma membrane and forms a heterotetramer with annexin A2. The heterotetramer, comprising of two subunits of annexin A2 and S100A10, activates the plasminogen activation pathway, which is involved ...
Martin K. Oehler, Noye, T.M., Tannith M. Noye, Lokman, N.A., Noor A. Lokman, Oehler, M.K., Carmela Ricciardelli, Ricciardelli, C.   +7 more
core   +1 more source

Complex formation and submembranous localization of annexin 2 and S100A10 in live HepG2 cells

, 2001
The Ca2+ and membrane binding protein annexin 2 can form a heterotetrameric complex with the S100A10 protein and this complex is thought to serve a bridging or scaffolding function in the membrane underlying cytoskeleton.
Nicole Zobiack, Zobiack, Nicole, Gerke, Volker, Rescher, Ursula, Ursula Rescher, Volker Gerke   +5 more
core   +1 more source

The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients

Annals of Surgery, 2019
Objective: To determine the characteristics of trauma patients with low levels of fibrinolysis as detected by viscoelastic hemostatic assay (VHA) and explore the underlying mechanisms of this subtype. Background: Hyperfibrinolysis is a central component of acute traumatic ...
Gall, LS, Vulliamy, P, Gillespie, S, Jones, TE, Pierre, RSJ, Breukers, SE, Gaarder, C, Juffermans, NP, Maegele, M, Stensballe, J, Johansson, PI, Davenport, RA, Brohi, K, Kolstadbraaten, KM, Baksaas-Aasen, K, Naess, PA, Ostrowski, SR, Vrangbaek, K, Bergmann, R, Hansen, SK, Rourke, C, Goerlinger, K, Hochleitner, M, Dias, J, Stanworth, SJ, Curry, N, Stuermer, EK, Schaefer, N, Driessen, A, Balvers, K, van Dieren, S, Harrison, M, Soyel, H, Trauma-Indu, TAC   +33 more
openaire   +7 more sources

Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites

, 2011
Macrophages are critical drivers of tumor growth, invasion, and metastasis. Movement of macrophages into tumors requires the activity of cell surface proteases such as plasmin. In this study, we offer genetic evidence that plasminogen receptor S100A10 is
Kyle D. Phipps, Alexi P. Surette, David M. Waisman, Paul A. O'Connell   +3 more
core   +1 more source

S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma. [PDF]

, 2019
Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance.
Fuh, Katherine, Miao, Yu, Tian, Lei, Xiao, Yiren, Ernst, Anne, Brooks, James, Peehl, Donna, Diep, Anh, Leppert, John, Nolley, Rosie, Rankin, Erinn, Giaccia, Amato, Zhao, Hongjuan, von Eyben, Rie   +13 more
core   +1 more source

Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2

, 2010
Protein–protein interactions are increasingly of interest as targets in small-molecule drug discovery. The interaction between the Ca2+- and phospholipid-binding protein Annexin A2 and its binding partner S100A10 has been implicated in angiogenesis and ...
Fischer, Peter M., Dekker, Lodewijk V., Reddy, Tummala Rama Krishna, Li, Chan   +3 more
core   +1 more source

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction [PDF]

, 2014
Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer.
Fischer, Peter M., Reddy, Tummala R.K., Dekker, Lodewijk V., Dekker, Lodewijk, Reddy, Tummala Rama Krishna, Fischer, Peter, Guo, Xiaoxia, Li, Chan   +7 more
core   +1 more source

Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. [PDF]

, 2003
Item does not contain fulltextTRPV5 and TRPV6 constitute the Ca(2+) influx pathway in a variety of epithelial cells. Here, we identified S100A10 as the first auxiliary protein of these epithelial Ca(2+) channels using yeast two-hybrid and GST pull-down ...
van de Graaf, S. F.J., van de Graaf, Stan F. J., Gerke, V., Gerke, Volker, Graaf, K.F.J. van de, Gerke, V., Prenen, Jean, Graaf, Stan F J van De, Gkika, Dimitra, Gkika, D., Staub, O., Hoenderop, J.G.J., Lamers, D., Nilius, B., van de Graaf, S. F., Bindels, René J. M., Prenen, J., Bindels, R.J.M., Lamers, D.W.L., Nilius, Bernd, Gkika, D., Rescher, Ursula, Bindels, René J M, Staub, O., Prenen, J., Staub, Olivier, Hoenderop, Joost G J, Rescher, U., Bindels, R. J., Lamers, Dennis, Nilius, B., Rescher, U., Hoenderop, Joost G. J., Hoenderop, J. G.   +33 more
core   +1 more source