Results 51 to 60 of about 15,017 (189)

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

The Annexin A2/S100A10 System in Health and Disease: Emerging Paradigms [PDF]

Journal of Biomedicine and Biotechnology, 2012
Since its discovery as a src kinase substrate more than three decades ago, appreciation for the physiologic functions of annexin A2 and its associated proteins has increased dramatically. With its binding partner S100A10 (p11), A2 forms a cell surface complex that regulates generation of the primary fibrinolytic protease, plasmin, and is dynamically ...
Hedhli, Nadia, Falcone, Domenick J., Huang, Bihui, Cesarman-Maus, Gabriela, Kraemer, Rosemary, Zhai, Haiyan, Tsirka, Stella E., Santambrogio, Laura, Hajjar, Katherine A.   +8 more
openaire   +2 more sources

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel–Palade body exocytosis in endothelial cells [PDF]

, 2017
Endothelial cells respond to blood vessel injury by the acute release of the procoagulant von Willebrand factor, which is stored in unique secretory granules called Weibel–Palade bodies (WPBs). Stimulated WPB exocytosis critically depends on their proper
Neeft, Maaike, Koch, Henriette, Martin, T., Van der Sluijs, P., Santos, Nina, Gerke, V., Wojcik, Sonja, Mostov, Keith E., Santos, Nina Criado, Volker Gerke, Disse, J., Anna Holthenrich, Tarek Chehab, Koerdt, S., Man, K., Nazmi, A., Disse, Jennifer, Schuberth, Christian, Sophia N. Koerdt, Kwun Nok M. Man, Christian Schuberth, Chehab, T., Peter van der Sluijs, Brose, Nils, Henriette Koch, Criado Santos, N., van der Sluijs, Peter, Neeft, M., Brose, N., Man, Kwun Nok M., Nils Brose, Gerke, Volker, Koch, H., Nazmi, Ali, Sonja M. Wojcik, Wojcik, S., Martin, Thomas F. J., Schuberth, C., Maaike Neeft, Holthenrich, Anna, Koerdt, Sophia, Man, Kwun Nok Mimi, Koerdt, Sophia N., Nazmi, Ali Reza, Chehab, Tarek, Martin, Thomas, Ali Reza Nazmi, Nina Criado Santos, Jennifer Disse, Wojcik, Sonja M., Holthenrich, A., Thomas F. J. Martin   +51 more
core   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

High Migration and Invasion Ability of PGCCs and Their Daughter Cells Associated With the Nuclear Localization of S100A10 Modified by SUMOylation

Frontiers in Cell and Developmental Biology, 2021
Our previous studies have confirmed that cobalt chloride (CoCl2) or chemoradiotherapy could induce the formation of polyploid tumor giant cells (PGCCs).
Qi Zhao, Kexin Zhang, Zugui Li, Hao Zhang, Fangmei Fu, Junjie Fu, Minying Zheng, Shiwu Zhang   +7 more
semanticscholar   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Elucidating the role of S100A10 in CD8+ T cell exhaustion and HCC immune escape via the cPLA2 and 5-LOX axis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a common malignant tumor with a complex immune evasion mechanism posing a challenge to treatment. The role of the S100A10 gene in various cancers has garnered significant attention.
Ganggang Wang, Xiaowei Shen, Wenzhi Jin, Chao Song, Meiyuan Dong, Zhijie Zhou, Xiaoliang Wang   +6 more
semanticscholar   +1 more source

S100A10 silencing suppresses proliferation, migration and invasion of ovarian cancer cells and enhances sensitivity to carboplatin

, 2019
Background Ovarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis.
Tanxiu Chen, Zhumei Cui, Liang Zou, Xukun Li, Tian Tian, Wei Yan, Zhihua Liu, Lingzhi Wang   +7 more
core   +1 more source

S100A10 protein expression is associated with oxaliplatin sensitivity in human colorectal cancer cells [PDF]

, 2011
Background Individual responses to oxaliplatin (L-OHP)-based chemotherapy remain unpredictable. The objective of our study was to find candidate protein markers for tumor sensitivity to L-OHP from intracellular proteins of human colorectal cancer (CRC ...
Nishimuta Akito, Yamayoshi Yasuko, Suzuki Sayo, Tanigawara Yusuke   +3 more
core   +1 more source