Results 71 to 80 of about 613,651 (294)

Whole-Genome Analysis of a Novel Fish Reovirus (MsReV) Discloses Aquareovirus Genomic Structure Relationship with Host in Saline Environments

Viruses, 2015
Aquareoviruses are serious pathogens of aquatic animals. Here, genome characterization and functional gene analysis of a novel aquareovirus, largemouth bass Micropterus salmoides reovirus (MsReV), was described.
Zhong-Yuan Chen, Xiao-Chan Gao, Qi-Ya Zhang   +2 more
doaj   +1 more source

Additional file 1: Figure S1. of Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids

, 2017
Aminoacid variability of all obtained MHC IIB sequences. Figure S2. Phylogenetic inference tree of MHC IIB alleles. Figure S3. Estimate of evolutionary divergence between sequences that support allele groupings. Table S1. List of samples used for this study, Species, Lake and ID numbers are given. Table S2.
Hofmann, Melinda, Bracamonte, Seraina, Eizaguirre, Christophe, Barluenga, Marta   +3 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multiple gene analyses identify distinct “bois noir” phytoplasma genotypes in the Republic of Macedonia

Phytopathologia Mediterranea, 2014
“Bois noir” (BN) is a grapevine yellows disease, associated with phytoplasma strains related to ‘Candidatus Phytoplasma solani’, that causes severe losses to viticulture in the Euro-Mediterranean basin.
Emilija KOSTADINOVSKA, Fabio QUAGLINO, Sasa MITREV, Paola CASATI, Daniela BULGARI, Piero BIANCO   +5 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Stroma-specific gene expression signature identifies prostate cancer subtype with high recurrence risk

npj Precision Oncology
Current prognostic tools cannot clearly distinguish indolent and aggressive prostate cancer (PC). We hypothesized that analyzing individual contributions of epithelial and stromal components in localized PC (LPC) could improve risk stratification, as ...
Martin Rasmussen, Jacob Fredsøe, Paul Vinu Salachan, Marcus Pii Lunau Blanke, Stine Hesselby Larsen, Benedicte Parm Ulhøi, Jørgen Bjerggaard Jensen, Michael Borre, Karina Dalsgaard Sørensen   +8 more
doaj   +1 more source

Polymorphism of alpha s1-casein gene in a dairy goat herd in the southeastern region of Brazil Polimorfismo do gene da alpha s1-caseína em um rebanho leiteiro na região sudeste do Brasil

Revista Brasileira de Zootecnia, 2009
Three different regions of the alpha s1-casein gene (CSN1S1) were investigated to determine the frequencies of major alleles for null, low, intermediate and high milk protein expression in a herd of dairy goats raised in the southeastern region of Brazil.
Maria Amélia Menck Soares, Marcelo Teixeira Rodrigues, Giuliana Patrícia Mognol, Lucinéia de Fátima Chasko Ribeiro, José Luis da Conceição Silva, Rose Meire Costa Brancalhão   +5 more
doaj   +1 more source