Results 231 to 240 of about 317,828 (311)

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

open access: yesThe FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger   +4 more
wiley   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

open access: yesThe FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

UbiB proteins mediate an ATP‐dependent decarboxylation step in bacterial ubiquinone biosynthesis

open access: yesThe FEBS Journal, EarlyView.
UbiB proteins are atypical protein kinase‐like enzymes essential for ubiquinone biosynthesis. Here, we demonstrate that bacterial UbiB proteins catalyze the O2‐dependent decarboxylation of ubiquinone precursors, a process linked to their ATPase activity.
Katayoun Kazemzadeh   +12 more
wiley   +1 more source

The transport of protein aggregates to the vacuole suggests a role for lipid droplets in waste disposal in Saccharomyces cerevisiae

open access: yesThe FEBS Journal, EarlyView.
Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter   +15 more
wiley   +1 more source

Safety and Effectiveness of Probiotic Preparations: A Contemporary Review. [PDF]

open access: yesDiseases
Shorabaev E   +6 more
europepmc   +1 more source

The harnessing potential of carboxymethyl beta glucan: A driver of skin repair

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Carboxymethyl Beta‐Glucan (CM‐BG) drives skin repair through multifaceted actions, notably in wounded 3D models. It activates Dectin‐1 and mitigates inflammation (reducing pro‐inflammatory mediators, boosting anti‐inflammatory IL‐10) in cellular models, while enhancing epidermal differentiation and collagen I synthesis by fibroblasts across cellular ...
Caroline Pichon   +4 more
wiley   +1 more source

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