Results 271 to 280 of about 635,476 (340)
The FEBS Journal, EarlyView.Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron +5 more
wiley +1 more source
Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’
The FEBS Journal, EarlyView.Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko +2 more
wiley +1 more source
Blood group O expression in normal tissues and tumors
The FEBS Journal, EarlyView.The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin +11 more
wiley +1 more source
The FEBS Journal, EarlyView.Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický +22 more
wiley +1 more source
Competition between binding partners of yeast Pex3 affects peroxisome biology
The FEBS Journal, EarlyView.Pex3 is a peroxisomal membrane protein (PMP) that specifically recruits several binding partners. In the yeast Hansenula polymorpha, Atg30 (pexophagy), Inp1 (inheritance) and Pex19 (receptor for new PMPs) associate with Pex3. Overexpression of any of these proteins affects peroxisomal processes because these proteins compete for binding to Pex3.
Eline M. F. de Lange +5 more
wiley +1 more source
Csn5 Depletion Reverses Mitochondrial Defects in GCN5-Null <i>Saccharomyces cerevisiae</i>. [PDF]
Int J Mol SciCirigliano A +6 more
europepmc +1 more source
The FEBS Journal, EarlyView.We revealed the crystal structure of eKatE from atypical E. coli. eKatE exhibits a hydrogen‐peroxide‐sensitive major channel, a stabilized dimeric interface, an unusual covalent bond between C392 and Y415, and other distinctive features. These structural features contribute to its enhanced catalase activity compared to KatE in typical E.
Eunhee Koh +7 more
wiley +1 more source
Gene promoters are genomically encoded to facilitate histone exchange/incorporation. [PDF]
PLoS BiolBartholomew B.
europepmc +1 more source
The FEBS Journal, EarlyView.A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina +9 more
wiley +1 more source
Production of Lambic-like Fruit Sour Beer with <i>Lachancea thermotolerans</i>. [PDF]
Antioxidants (Basel)Bartolomé R +3 more
europepmc +1 more source