HTD1265 Disrupts GimC-Dependent Cellular Processes in <i>Saccharomyces cerevisiae</i>. [PDF]
Itto-Nakama K +10 more
europepmc +1 more source
Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley +1 more source
Oxidative stress response of <i>Saccharomyces cerevisiae</i> exposed to different molecular weight of polycyclic aromatic hydrocarbons. [PDF]
Takam P +2 more
europepmc +1 more source
Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara +5 more
wiley +1 more source
Ubiquitin-conjugating enzyme membrane anchor Cue1 confers resistance to hygromycin B in <i>Saccharomyces cerevisiae</i>. [PDF]
Avaala JA +7 more
europepmc +1 more source
In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková +7 more
wiley +1 more source
Kinetic sampling shows the effect of medium composition on metabolic control in Saccharomyces cerevisiae. [PDF]
de Leeuw M, Nielsen LK.
europepmc +1 more source
ABSTRACT Disease outbreaks and the associated reliance on antibiotics pose major constraints to the sustainability of modern aquaculture. As regulatory pressures increase and consumer demand shifts toward residue‐free production, diverse biological interventions are gaining prominence as viable alternatives to chemotherapeutics.
Mustafa Öz +5 more
wiley +1 more source
Mistranslating tRNA variants impact the proteome and phosphoproteome of Saccharomyces cerevisiae. [PDF]
Berg MD +3 more
europepmc +1 more source
Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang +8 more
wiley +1 more source

