Results 121 to 130 of about 274,580 (343)

Combining face‐to‐face laboratory sessions and a computer simulation effectively teaches gene editing and DNA sequencing to undergraduate genetics students

Biochemistry and Molecular Biology Education, EarlyView.
Abstract Innovative approaches to teaching genetics are essential for improving student engagement and comprehension in this challenging field. Laboratory‐based instruction enhances engagement with the subject while fostering the development of practical competencies and deepening comprehension of theoretical concepts.
Chris Della Vedova, Gareth Denyer, Maurizio Costabile   +2 more
wiley   +1 more source

Crystal structure of Methanococcus jannaschii dihydroorotase

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 1, Page 91-98, January 2023., 2023
Abstract In this paper, we report the structural analysis of dihydroorotase (DHOase) from the hyperthermophilic and barophilic archaeon Methanococcus jannaschii. DHOase catalyzes the reversible cyclization of N‐carbamoyl‐l‐aspartate to l‐dihydroorotate in the third step of de novo pyrimidine biosynthesis.
Jacqueline Vitali, Jay C. Nix, Haley E. Newman, Michael J. Colaneri   +3 more
wiley   +1 more source

Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and Metabolic Saccharomyces cerevisiae Proteins. [PDF]

Pharmaceuticals (Basel), 2022
Santos MFDS, Freitas CS, Verissimo da Costa GC, Pereira PR, Paschoalin VMF.   +4 more
europepmc   +1 more source

Experimental design trade-offs for gene regulatory network inference: an in silico study of the yeast Saccharomyces cerevisiae cell cycle [PDF]

arXiv, 2017
Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a set of quantitative guidelines that prescribe the minimal number of samples required to infer a reliable GRN model. We study the temporal resolution of
arxiv  

An application of node and edge nonlinear hypergraph centrality to a protein complex hypernetwork [PDF]

PloS one. 2024;19(10):e0311433
The use of graph centrality measures applied to biological networks, such as protein interaction networks, underpins much research into identifying key players within biological processes. This approach however is restricted to dyadic interactions and it is well-known that in many instances interactions are polyadic.
arxiv   +1 more source

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America, 1997
The cyclophilins and FK506 binding proteins (FKBPs) bind to cyclosporin A, FK506, and rapamycin and mediate their immunosuppressive and toxic effects, but the physiological functions of these proteins are largely unknown.
Kara Dolinski, Scott Muir, Maria E. Cardenas, Joseph Heitman   +3 more
semanticscholar   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.

Nucleic Acids Research, 1997
The availability of the complete sequence of the Saccharomyces cerevisiae genome has allowed a comprehensive analysis of the genes encoding cytoplasmic ribosomal proteins in this organism.
W. Mager, R. Planta, J. Ballesta, John C. Lee, K. Mizuta, K. Suzuki, J. R. Warner, J. Woolford   +7 more
semanticscholar   +1 more source

A method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli

Biotechnology Progress, EarlyView.
Abstract Variable lymphocyte receptors (VLRs) are the antigen receptors of jawless vertebrates such as lamprey. VLRs are of growing biotechnological interest for their ability to bind certain antigenic targets with higher affinity than traditional immunoglobulins.
Elizabeth A. Appelt, James B. Thoden, Candis Dancy, Hannah D. Bachmeier, Seth A. Gehrke, Melanie A. Staffenson, Ivan Rayment, Moriah E. Katt, Hazel M. Holden, Eric V. Shusta   +9 more
wiley   +1 more source

How the global structure of protein interaction networks evolves [PDF]

arXiv, 2002
Two processes can influence the evolution of protein interaction networks: addition and elimination of interactions between proteins, and gene duplications increasing the number of proteins and interactions. The rates of these processes can be estimated from available Saccharomyces cerevisiae genome data and are sufficiently high to affect network ...
arxiv