Results 21 to 30 of about 137,997 (266)

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast

open access: yesG3: Genes, Genomes, Genetics, 2021
Life requires the oligomerization of individual proteins into higher-order assemblies. In order to form functional oligomers, monomers must adopt appropriate 3D structures.
Ashley S Denney   +2 more
doaj   +1 more source

Evaluation of Unconventional Protein Secretion by Saccharomyces cerevisiae and other Fungi

open access: yesCells, 2018
Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences.
Natsuko Miura, Mitsuyoshi Ueda
doaj   +1 more source

Identification of novel human damage response proteins targeted through yeast orthology. [PDF]

open access: yesPLoS ONE, 2012
Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S.
J Peter Svensson   +4 more
doaj   +1 more source

Glycolytic Proteins Interact With Intracellular Melatonin in Saccharomyces cerevisiae

open access: yesFrontiers in Microbiology, 2019
Melatonin is a bioactive compound that is present in fermented beverages and synthesized by yeast during alcoholic fermentation. Many studies have shown that melatonin interacts with some mammalian proteins, such as sirtuins or orphan receptor family ...
María Ángeles Morcillo-Parra   +4 more
doaj   +1 more source

Control of yeast retrotransposons mediated through nucleoporin evolution. [PDF]

open access: yesPLoS Genetics, 2018
Yeasts serve as hosts to several types of genetic parasites. Few studies have addressed the evolutionary trajectory of yeast genes that control the stable co-existence of these parasites with their host cell.
Paul A Rowley   +3 more
doaj   +1 more source

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

open access: yesG3: Genes, Genomes, Genetics, 2016
The TTT complex is composed of the three essential proteins Tel2, Tti1, and Tti2. The complex is required to maintain steady state levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1,
Kyle S. Hoffman   +5 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

An outlook to sophisticated technologies and novel developments for metabolic regulation in the Saccharomyces cerevisiae expression system

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Saccharomyces cerevisiae is one of the most extensively used biosynthetic systems for the production of diverse bioproducts, especially biotherapeutics and recombinant proteins. Because the expression and insertion of foreign genes are always impaired by
Yijian Wu   +5 more
doaj   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

open access: yesFEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu   +4 more
wiley   +1 more source

Saccharomyces cerevisiae: a versatile eukaryotic system in virology

open access: yesMicrobial Cell Factories, 2007
The yeast Saccharomyces cerevisiae is a well-established model system for understanding fundamental cellular processes relevant to higher eukaryotic organisms.
Breinig Tanja   +5 more
doaj   +1 more source

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