Results 71 to 80 of about 137,997 (266)
Nature Communications, 2020 The conserved eukaryotic heterotrimeric NatC complex co-translationally acetylates the N-termini of numerous target proteins. Here, the authors provide insights into the catalytic mechanism of NatC by determining the crystal structures of Saccharomyces ...
Stephan Grunwald +5 more
doaj +1 more source
ChemBioChem, EarlyView.A cyclized helix‐loop‐helix (cHLH) peptide is used as a molecular scaffold to generate cell‐permeable protein–protein interactions inhibitors by bifunctional grafting. The steroid receptor coactivator‐1 (SRC1) epitope (red) was grafted onto the C‐terminal helix, and six arginine residues (cyan) were grafted onto the other helix.
Daisuke Fujiwara +8 more
wiley +1 more source
Mammalian Tolerance to Amino Acid Heterochirality
ChemBioChem, EarlyView.Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi +4 more
wiley +1 more source
Fermentation, 2017 Yeasts involved in veil formation during biological ageing of Sherry wines are mainly Saccharomyces cerevisiae, and they have traditionally been divided into four races or varieties: beticus, cheresiensis, montuliensis and rouxii.
Marina Ruíz-Muñoz +5 more
doaj +1 more source
In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
ChemBioChem, Accepted Article.Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska +2 more
wiley +1 more source
Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering
ChemCatChem, EarlyView.A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer +7 more
wiley +1 more source
Specific Dissociation of Ribosomes from Saccharomyces cerevisiae by a Protein Factor [PDF]
, 1970 Jean Pétré
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Chemie Ingenieur Technik, EarlyView.The combination of methanol synthesis and biotechnological upgrading to value‐added products still faces some challenges in order to achieve a positive environmental impact and thus the goal of synergetic development of biotechnological and chemical processes.
Mehran Taherkhani +3 more
wiley +1 more source
The Dicyclohexylcarbodiimide‐Binding Protein of the Mitochondrial ATPase Complex from Neurospora crassa and Saccharomyces cerevisiae [PDF]
, 1979 Walter Sebald +2 more
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ChemSusChem, EarlyView.An experimental and computational investigation on the regio‐ and enantioselective hydroxylation of arachidonic acid by several unspecific peroxygenases (UPOs) revealed rAaeUPO A77L variant as the most attractive candidate for the selective production of valuable hydroxy‐fatty acids because of its enhanced regio and enantioselectivity and reduced ...
Alejandro González‐Benjumea +7 more
wiley +1 more source