Results 101 to 110 of about 262,483 (141)

Population Pharmacokinetics of the Novel Myeloperoxidase Inhibitor Mitiperstat

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Mitiperstat is a novel myeloperoxidase inhibitor being investigated for the treatment of heart failure, metabolic dysfunction‐associated steatohepatitis, and chronic obstructive pulmonary disease. Pharmacokinetic data from five clinical trials were used to develop a mitiperstat population pharmacokinetics (popPK) model.
Mikael Sunnåker, Jacob Leander, Hans Ericsson   +2 more
wiley   +1 more source

Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibiting TRIM25 oligomerization and functional activation of RIG-I/TRIM25

Veterinary Research
Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging Alpha-coronavirus, brings huge economic loss in swine industry. Interferons (IFNs) participate in a frontline antiviral defense mechanism triggering the activation of numerous downstream ...
Jiyu Zhang, Hongyan Shi, Liaoyuan Zhang, Tingshuai Feng, Jianfei Chen, Xin Zhang, Zhaoyang Ji, Zhaoyang Jing, Xiaoyuan Zhu, Dakai Liu, Xiaoman Yang, Miaomiao Zeng, Da Shi, Li Feng   +13 more
doaj   +1 more source

STING agonist diABZI confers protection against swine acute diarrhea syndrome coronavirus in neonatal mice by activating antiviral immunity

Journal of Virology
The recently identified alphacoronavirus swine acute diarrhea syndrome coronavirus (SADS-CoV) has a high fatality rate in neonatal piglets. Currently, no vaccines or treatment strategies for SADS-CoV infection are available.
Yuying Li, Wei Chen, Xinyu Zhang, Jiyong Zhou, Yanqing Hu, Yimin Zhou, Tian Lan, Haixin Huang, Lulu Xie, Yan Qin, Lin Zhou, Wenchao Sun, HuiJun Lu   +12 more
doaj   +1 more source

Porcine intestinal enteroid (PIE) cultures can support SADS-CoV replication.

, 2022
(A) 3D PIEs were derived from small intestinal crypts and cultured in Matrigel. (B) Single cell suspensions from the 3D PIEs were seeded in Matrigel-coated 96-well plates to form 2D enteroid monolayers.
Chan Ding (317445), Yao-Wei Huang (426136), Shu Jeffrey Zhu (12867687), Yi-Xin Tang (12867684), Pan Qin (6517490), Qi-Yue Yang (12867681), Shu-Xian Chen (10719084), Jin-Yan Xie (9920614), Yong-Le Yang (10977618), Gan Wang (786657)   +9 more
core   +1 more source

Pandemic emergency: A multi‐level AI framework for analyzing psychological impact through public discourse

Applied Psychology: Health and Well-Being, Volume 18, Issue 3, June 2026.
Abstract Emergency management has become a widely discussed topic in recent years, particularly in relation to different types of emergencies such as climate change, natural disasters, public health, and armed conflicts. The Covid‐19 pandemic has triggered unprecedented uncertainty, sparking a global emergency that raised concerns not only about health
Luisa Orrù, Stefania Mannarini
wiley   +1 more source

Development of an indirect enzyme-linked immunosorbent assay based on nucleocapsid protein for the detection of swine acute diarrhea syndrome coronavirus antibody

Virology Journal
Background Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a porcine enteric coronavirus that induces watery diarrhea in pigs, causing substantial economic losses in the swine industry. While the molecular and serological epidemiology of SADS-CoV
Yu-Jeong Jang, Nam Phuong Le, Eun-Song Lee, Min-Chae Kim, Tae-Kyung Chang, Jung-Eun Park   +5 more
doaj   +1 more source

Cryo-electron microscopy structure of the SADS-CoV spike glycoprotein provides insights into an evolution of unique coronavirus spike proteins [PDF]

, 2020
Abstract The current outbreak of Coronavirus Disease 2019 (COVID-19) by a novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has aroused great public health concern. Coronavirus has a history of causing epidemics in human and animals.
Guan H, Wang Y, Saeed AF, Li J, Jan SS, Perčulija V, Li Y, Zhu P, Ouyang S.   +8 more
europepmc   +2 more sources

Childbirth in Women Infected or in Close Contact With SARS‐CoV‐2 in Spain: A Qualitative Study

Birth, Volume 53, Issue 2, Page 370-378, June 2026.
During the first wave of the COVID‐19 pandemic in Spain (March–June 2020), nineteen pregnant women who were either infected or in isolation reported significant uncertainty regarding the disease, a perceived loss of control, and the emotional impact of neonatal restrictions. Childbirth was frequently described as a traumatic experience, emphasizing the
Paula Parás‐Bravo, Domingo Palacios‐Ceña, Paloma Moro‐López‐Menchero, Manuel Herrero‐Montes, Cesar Fernandez‐de‐las‐Peñas, Maria Jesus Cabero, Carolina Lechosa‐Muñiz   +6 more
wiley   +1 more source

Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus

, 2022
Coronaviruses as possible cross-species viruses have caused several epidemics. The ongoing emergency of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has posed severe threats to the global economy and public health, which has generated great ...
Zhu, Shaozhou, Song, Lihua, Yangzhen Chen, Yigang Tong, Jiang, Lin, An, Xiaoping, Lili Tian, Xiaoping An, Huahao Fan, Fan, Huahao, Shuqi Wang, Lin Jiang, Tian, Lili, Tong, Yigang, Chen, Yangzhen, You, Yecheng, Lihua Song, Wang, Shuqi, Shaozhou Zhu, Yecheng You   +19 more
core   +1 more source

Recombinant porcine interferon delta 8 inhibits swine acute diarrhoea syndrome coronavirus infection in vitro and in vivo

Veterinary Research
Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which originates from zoonotic transmission of bat coronaviruses in the HKU2 lineage, causes severe illness in pigs and carries a high risk of spreading to humans.
Teng Zhang, Jiale Yao, Zhuan Yang, Jucai Wang, Kankan Yang, Lunguang Yao   +5 more
doaj   +1 more source