Results 91 to 100 of about 2,271,128 (293)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Case Studies in Construction MaterialsThe widespread occurrence of toxic arsenic in sulfidic and non-ferrous waste tailings hinders its disposal as cement paste backfill (CPB). Alkali activated slag (AAS) has recently begun to be practiced as an alternative to normal Portland cement (OPC ...
Haiqiang Jiang +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Is “Small” Safe? Exploring the Good and Bad of Nanomaterials
Frontiers for Young Minds“Small” does not necessarily have a clear meaning… is a ball big or small? A ball might be small compared to the entire planet, but it is absolutely huge compared to tiny “nano” particles! If you look at 1 mm on a ruler, one million nanometers can fit into that millimeter.
Boodhia, K, Andraos, C, Botha, T
openaire +2 more sources
Diverse Exploration for Fast and Safe Policy Improvement
Proceedings of the AAAI Conference on Artificial Intelligence, 2018 We study an important yet under-addressed problem of quickly and safely improving policies in online reinforcement learning domains. As its solution, we propose a novel exploration strategy - diverse exploration (DE), which learns and deploys a diverse set of safe policies to explore the environment.
Andrew Cohen, Lei Yu 0001, Robert Wright
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Безопасность информационных технологийStriking a balance between safety and performance remains a critical concern, despite advancements in the field. To address this issue, a versatile framework named Safety Goes Along with Performance (SGAWP) is proposed, centered on off-policy algorithms ...
Mohsen Abdollahzadeh Aghbolagh
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Contextual Affordances for Safe Exploration in Robotic Scenarios
CoRRRobotics has been a popular field of research in the past few decades, with much success in industrial applications such as manufacturing and logistics. This success is led by clearly defined use cases and controlled operating environments. However, robotics has yet to make a large impact in domestic settings.
William Z. Ye +3 more
openaire +3 more sources