Results 31 to 40 of about 5,613,091 (316)

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.

New England Journal of Medicine, 2012
BACKGROUND Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune system.
J. Brahmer, S. Tykodi, L. Chow, W. Hwu, S. Topalian, P. Hwu, C. Drake, L. Camacho, J. Kauh, K. Odunsi, H. Pitot, O. Hamid, S. Bhatia, R. Martins, K. Eaton, Shuming Chen, Theresa M Salay, S. Alaparthy, J. Grosso, A. Korman, S. Parker, S. Agrawal, S. M. Goldberg, D. Pardoll, A. Gupta, J. Wigginton   +25 more
semanticscholar   +1 more source

December 2019-Printed Issue

Patient Safety, 2019
We are proud to announce the publication of the second issue of our journal, Patient Safety. You can read it now at no charge at PatientSafetyJ.com or download a PDF.
Patient Safety Authority
doaj   +1 more source

June 2020-Printed Issue

Patient Safety, 2020
The summer 2020 issue of Patient Safety is available to read and download at no charge. Each issue of Patient Safety delivers new evidence-based research and data analytics, engaging editorials, inspiring stories from patients and families, and ...
Patient Safety Authority
doaj   +1 more source

End-to-End Safe Reinforcement Learning through Barrier Functions for Safety-Critical Continuous Control Tasks [PDF]

AAAI Conference on Artificial Intelligence, 2019
Reinforcement Learning (RL) algorithms have found limited success beyond simulated applications, and one main reason is the absence of safety guarantees during the learning process.
Richard Cheng, G. Orosz, R. Murray, J. Burdick   +3 more
semanticscholar   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

September 2019-Printed Issue

Patient Safety, 2019
Welcome to the first issue of Patient Safety! Brought to you by the Patient Safety Authority, an independent agency of the Commonwealth of Pennsylvania, this brand-new journal is unlike any other you’ve seen. Since patients are at the heart of everything
Patient Safety Authority
doaj   +1 more source

The REporting of A Disproportionality Analysis for DrUg Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Explanation and Elaboration

Drug Safety
In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect safety signals. Unfortunately, publishing disproportionality analyses lacks specific guidelines, often leading to incomplete and ambiguous
M. Fusaroli, Francesco Salvo, Bernard Bégaud, T. Alshammari, Andrew Bate, V. Battini, Andreas Brueckner, G. Candore, Carla Carnovale, Salvatore Crisafulli, P. Cutroneo, Charles Dolladille, M. Drici, J. Faillie, Adam Goldman, M. Hauben, M. T. Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G. N. Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, E. Poluzzi, Myriam Salem, D. Sartori, N. T. Trinh, Marco Tuccori, Florence van Hunsel, E. V. van Puijenbroek, Emanuel Raschi, C. Khouri   +33 more
semanticscholar   +1 more source