Results 61 to 70 of about 3,948,851 (307)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Acknowledgement to Reviewers of Safety in 2016

open access: yesSafety, 2017
n ...
Safety Editorial Office
doaj   +1 more source

Conclusion on the peer review of the pesticide risk assessment of the active substance amitrole [PDF]

open access: yesEFSA Journal, 2014
The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance amitrole are reported.
European Food Safety Authority
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Importance of Safety Equity in Transportation System Safety

open access: yes, 2022
  Public transportation in the U.S. often relies on multi-modal components that represent a system of systems as exemplified by transit rail. Currently, transit rail safety is measured for individual railroads as the number of events/fatalities ...
Garcia, Anne
core   +1 more source

Conclusion on the peer review of the pesticide risk assessment of confirmatory data submitted for the active substance lenacil [PDF]

open access: yesEFSA Journal, 2013
The conclusions of the European Food Safety Authority (EFSA) following the peer review of an initial risk assessment carried out by the competent authority of the rapporteur Member State Belgium, relating to the pesticide active substance lenacil are ...
European Food Safety Authority
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Conclusion on the peer review of the pesticide risk assessment of the active substance penflufen [PDF]

open access: yesEFSA Journal, 2012
<p>The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the United Kingdom, for the pesticide active substance ...
European Food Safety Authority
doaj   +1 more source

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