Results 81 to 90 of about 4,778,747 (305)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Process Safety for OHS Professionals [PDF]
, 2016 PresentationProcess safety is a field dominated by engineers and OHS professionals come from a range of different disciplines. In addition to this process safety is often managed by engineers outside of the traditional safety function.
Kerin, Trish
core +1 more source
Low-Cost Pedestrian Safety Zones: Countermeasure Selection Resource [PDF]
Contract DTNH2216D00017/TaskOrder 693JJ919F000174This project consists of two reports, this one and Low-Cost Pedestrian Safety Zones: Countermeasure Selection Resource. They were developed for State Highway Safety Offices and transportation professionals
University of North Carolina at Chapel Hill. Highway Safety Research Center +2 more
core
System Safety in Organizational Safety Decision Making [PDF]
, 2016 The two cardinal aspects of safety are intrinsic safety and its demonstration. A key element of demonstrating system safety is the organizational structure that is best placed to ensure and demonstrate that high standards of safety are clearly in place ...
Jones, Malcolm
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Holding GLP-1 Agonists Prior to Elective Procedures
Patient Safety, 2023 Patient Safety Authority
doaj +1 more source
NIOSH Public Safety Program [PDF]
"What are our priorities? The National Institute for Occupational Safety and Health (NIOSH) Public Safety Program works with partners in industry, labor, trade associations, professional organizations, and academia.
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source