Results 51 to 60 of about 1,045,655 (263)

Safety and efficacy of STENOROL® (halofuginone hydrobromide) as a feed additive for chickens for fattening and turkeys

EFSA Journal, 2020
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the coccidiostat STENOROL® containing halofuginone hydrobromide (halofuginone ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Gabriele Aquilina, Paul Brantom, Georges Bories, Pier Sandro Cocconcelli, Jürgen Gropp, Guido Rychen, Orsolya Holczknecht, Maria Vittoria Vettori   +25 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Safety, efficacy and patient acceptability of the combined estrogen and progestin transdermal contraceptive patch: a review

Patient Preference and Adherence, 2008
Alessandra GraziottinCenter of Gynecology and Medical Sexology, H San Raffaele Resnati, Via Santa Croce 10/a, 20123 Milano, ItalyAbstract: The worldwide introduction of the first, unique patch for hormonal contraception (ethinyl estradiol/norelgestromin,
Alessandra Graziottin
doaj  

Psychedelics: Safety and Efficacy

International Journal of Environmental Research and Public Health
Psychedelic research has experienced a renaissance in recent years, with many researchers exploring the possible therapeutic effects of these drugs. Medical institutions, universities, pharmaceutical companies, and governmental institutions alike have been showing an increase in support of this research, as shown through the recent establishment of ...
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Iontophoretic Delivery of Hyaluronic Acid Nanogel-Loaded Fermented Rice Extract Mitigates Skin Glycation

International Journal of Nanomedicine
Yuanyuan Han,1,2,* Yunzhi Lin,3,* Miao Guo,4 Yinshu Wang,1,2 Xiuju Dong,1,2 Lidan Xiong,1,2 Li Li,1– 3 Hua Wang,4 Xuefeng Hu,5,6 Fan Yang4 1Evaluation Center for Cosmetics Safety and Efficacy, West China Hospital, Sichuan University ...
Han Y, Lin Y, Guo M, Wang Y, Dong X, Xiong L, Li L, Wang H, Hu X, Yang F   +9 more
doaj  

Safety and efficacy of laropiprant and extended-release niacin combination in the management of mixed  dyslipidemias and primary hypercholesterolemia

Drug, Healthcare and Patient Safety, 2010
Adie Viljoen1, Anthony S Wierzbicki21Lister Hospital, Stevenage, Hertfordshire, UK; 2Guy’s and St Thomas Hospitals, London, UKAbstract: Statins form the cornerstone of pharmaceutical cardiovascular disease prevention.
Adie Viljoen, Anthony S Wierzbicki
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS

International Journal of Women's Health, 2009
Paula H Bednarek, Jeffrey T JensenDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USAAbstract: Intrauterine devices (IUDs) provide highly effective, long-term, safe, reversible contraception, and are the most ...
Paula H Bednarek, Jeffrey T Jensen
doaj