Results 91 to 100 of about 8,110,163 (275)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dynamic Fumonisin B2 Production by Aspergillus niger Intented Used in Food Industry in China

Toxins, 2017
There are a total of 30 strains including 27 strains of Aspergillus niger intended used in Chinese food industry, two strains used as control and one strain isolated from corn for fumonisin (FB) production on 3 media.
Xiaomin Han, Hongru Jiang, Jin Xu, Jing Zhang, Fengqin Li   +4 more
doaj   +1 more source

Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue

Advancement of science, 2019
The production and application of nanomaterials have grown tremendously during last few decades. The widespread exposure of nanoparticles to the public is provoking great concerns regarding their toxicity to the human body.
Shuang Zhu, Linji Gong, Yijian Li, Haiwei Xu, Zhanjun Gu, Yuliang Zhao   +5 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Serotype distribution and antimicrobial resistance characteristics of Salmonella in chicken meat collected from wholesale markets in Beijing City

Zhongguo shipin weisheng zazhi
ObjectiveTo investigate the serotype distribution and antimicrobial resistance characteristics of Salmonella isolated from retail chicken in Beijing City.MethodsA total of 135 Salmonella strains were isolated from retail chicken meat collected from three
HU Yujie, WEN Yi, MA Yanning, HE Yingying, JIANG Tao, YU Dongmin, BAI Yao, XU Jin, LI Fengqin, DONG Yinping   +9 more
doaj   +1 more source

Road safety: the average male as a norm in vehicle occupant crash safety assessment

Interdisciplinary Science Reviews, 2019
This review addresses how women and men are represented in regulatory tests conducted to assess adult occupant safety in vehicles. Injury statistics show that protection in the event of a crash is lower for females than males. Still, vehicle crash safety
A. Linder, M. Svensson
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Optical Imaging Biomarkers of Drug-Induced Vascular Injury

Molecular Imaging, 2015
Drug-induced vascular injury (DIVI), defined as arterial medial degeneration/necrosis usually associated with perivascular inflammation, is frequently observed in the mesenteric arteries of rats but the relevance to humans remains a hurdle for drug ...
Shu-An Lin MS, Donna L. Suresch, Brett Connolly, Gebre Mesfin, Raymond J. Gonzalez, Manishkumar R. Patel, Diane Shevell, Timothy Johnson, Bohumil Bednar   +8 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

International journal of toxicology, 2019
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published ...
Christina L. Burnett, I. Boyer, W. Bergfeld, D. Belsito, Ronald A. Hill, C. Klaassen, D. Liebler, J. Marks, R. C. Shank, T. Slaga, P. Snyder, Lillian J. Gill, Bart A. Heldreth   +12 more
semanticscholar   +1 more source