Results 91 to 100 of about 3,040,361 (309)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Formal Safety and Security Assessment of an Avionic Architecture with Alloy
, 2014 We propose an approach based on Alloy to formally model and assess a system architecture with respect to safety and security requirements. We illustrate this approach by considering as a case study an avionic system developed by Thales, which provides ...
Brunel, Julien +4 more
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Scientific ReportsPesticides are indispensable tools in modern agriculture for enhancing crop productivity. However, the inherent toxicity of pesticides raises significant concerns regarding human exposure, particularly among agricultural workers.
Deuk-Yeong Lee +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Drug-Induced Oxidative Stress and Toxicity
Journal of Toxicology, 2012 Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their reactive nature
Damian G. Deavall +3 more
doaj +1 more source
Development of predicting model for safety behaviour based on safety psychology and working environment [PDF]
, 2018 The increasing trend of occupational accident due to unsafe act and unsafe condition especially in construction site suggests the need for more proactive safety assessment model.
Md Asari, Mohammad Khairul Shaleh
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Garigliano nuclear power plant: seismic evaluation of the turbine building [PDF]
, 2011 The Italian Garigliano Nuclear Power Plant (NPP) started its energy production in 1963. At present it is in the decommissioning stage. In order to get a proper management of the radioactive waste that will be produced during the dismantling operations it
E. Faccioli +4 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Patient safety in health care professional educational curricula: examining the learning experience [PDF]
, 2009 This study has investigated the formal and informal ways pre-registration students from four healthcare professions learn about patient safety in order to become safe practitioners.
Dawson, Pam +2 more
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