Results 211 to 220 of about 1,010,797 (263)
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International Journal of Antimicrobial Agents, 2003
Antibiotics usually have positive risk-benefit ratios, their adverse effects being generally mild and reversible on treatment cessation. However, severe adverse drug reactions (ADR), associated with significant mortality and morbidity have resulted in the withdrawal of several active antibiotics, including new fluoroquinolones.
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Antibiotics usually have positive risk-benefit ratios, their adverse effects being generally mild and reversible on treatment cessation. However, severe adverse drug reactions (ADR), associated with significant mortality and morbidity have resulted in the withdrawal of several active antibiotics, including new fluoroquinolones.
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Safety assurance and safety assessment
11th IET Professional Development Course on Railway Signalling and Control Systems, 2006`Safety first' is a maxim often quoted by those who are wise after the event. The railway industry has recently re-learnt this for itself because attempts to graft a safety argument on to an existing design have delayed many new trains and some infrastructure projects coming into service.
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HSE’s safety assessment principles for criticality safety
Journal of Radiological Protection, 2008The Health and Safety Executive (HSE) published its revised Safety Assessment Principles for Nuclear Facilities (SAPs) in December 2006. The SAPs are primarily intended for use by HSE's inspectors when judging the adequacy of safety cases for nuclear facilities.
D N, Simister +4 more
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The Quantitative Safety Assessment for Safety-Critical Software
29th Annual IEEE/NASA Software Engineering Workshop, 2006The software fault failure rate bound is discussed and generalized for different reliability growth models. The fault introduction during testing and the fault removal efficiency are modeled to relax the two common assumptions made in software reliability models.
Yangyang Yu, Barry W. Johnson
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2015
More and more young people practice climbing at a higher and higher level. Trying to reach excellence implies a rise in the number of training sessions and in the duration of these sessions, which consequently leads to an increase in injuries. Most of the common pathologies are found with high-level climbing.
Sébastien Gnecchi, François Moutet
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More and more young people practice climbing at a higher and higher level. Trying to reach excellence implies a rise in the number of training sessions and in the duration of these sessions, which consequently leads to an increase in injuries. Most of the common pathologies are found with high-level climbing.
Sébastien Gnecchi, François Moutet
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Independent Safety Assessment of Safety Arguments
2007The paper describes the role of Independent Safety Auditor (ISA) as carried out at the present in the defence and other sectors in the UK. It outlines the way the ISA role has developed over the past 15–20 years with the changing regulatory environment. The extent to which the role comprises audit, assessment or advice is a source of confusion, and the
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The safety assessment of fragrance materials
Regulatory Toxicology and Pharmacology, 2003Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials ...
David R, Bickers +8 more
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2020
In most clinical trials in phase II and III, the primary endpoint measures efficacy and therefore sample size calculation is based on this outcome. However, there are also situations were the primary objective concerns safety. Furthermore, even if sample size calculation is based on an efficacy endpoint, one is commonly interested which extent of ...
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In most clinical trials in phase II and III, the primary endpoint measures efficacy and therefore sample size calculation is based on this outcome. However, there are also situations were the primary objective concerns safety. Furthermore, even if sample size calculation is based on an efficacy endpoint, one is commonly interested which extent of ...
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Safety assessment of a new multivitamin
Food and Chemical Toxicology, 2012A newly created multivitamin possesses many protective health functions. To investigate its safety when applied in medical treatment and when used as a food supplement, we studied its acute oral toxicity and 13-week oral toxicity in mice. The results showed that the oral lethal dose, 50% (LD(50)) of the biomass of the multivitamin in mice was greater ...
Jun, Tao +6 more
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Toxicogenomics in Drug Safety Assessment
Pharmacogenomics, 2008Molecular investigative toxicology is an approach that the pharmaceutical industry has started to take more seriously in order to improve the drug discovery and development process, with the overall goal to reduce attrition. By combining traditional toxicology approaches with the development, validation and implementation of new technologies such as ...
Philip, Hewitt, Alexandra, Walijew
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