Results 221 to 230 of about 1,010,797 (263)

The assessment of drug safety for the fetus

International Journal of Clinical Pharmacy, 2020
Long standing concerns regarding the use of medications during pregnancy and their unknown effects on fetal development and child health suggests the need for modified study methods regarding the establishment of drug safety for the fetus. This Current Commentary highlights several pharmacological study method limitations and offers suggestions for the
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Safety assessment of Cordyceps guangdongensis

Food and Chemical Toxicology, 2010
Cordyceps guangdongensis as a kind of fungus, has been discovered and cultivated successfully in recent years. However, its safety assessments have not been studied. In this report, a serial of tests for toxicological safety assessments were depicted in details. These tests included bacterial reverse mutation (Ames) study, bone marrow cell micronucleus
Wen-juan, Yan, Tai-Hui, Li, Qun-ying, Lin, Bin, Song, Zi-de, Jiang   +4 more
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Software Safety Assessment and Probabilities

2016 46th Annual IEEE/IFIP International Conference on Dependable Systems and Networks Workshop (DSN-W), 2016
In a context where software is more and more pervasive in all systems, and where it is sometimes advocated that software complexity and size seem to provide some relevance to a probabilistic view of software behaviour, several initiatives suggest to change the way to address software in the global system safety assessment.
Jean-Paul Blanquart, Philippe Baufreton, Jean-Louis Boulanger, Jean-Louis Camus, Cyrille Comar, Hervé Delseny, Jean Gassino, Emmanuel Ledinot, Philippe Quéré, Bertrand Ricque   +9 more
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Assessment of safety-critical specifications

IEEE Software, 1994
Formal methods can reduce the ambiguity in specifications and provide a basis for verification later on/spl minus/especially important for safety-critical systems. The author compares specifications in the software cost reduction method and in the Vienna Definition Method for a safety-critical system and identifies several key assessment issues ...
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Safety Assessment in Pediatric Studies

2011
It typically takes many years before an association of a drug with a rare, serious adverse reaction is established. As related to pediatric drug use, evidence is even more erratic, as most drugs are used off labels. To enhance child safety, there is an urgent need to develop robust and rapid methods to identify such associations in as timely a manner ...
Gideon, Koren, Abdelbasset, Elzagallaai, Fatma, Etwel   +2 more
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Safety assessment of animal drugs

Regulatory Toxicology and Pharmacology, 1982
The Food and Drug Administration has published a proposal (Chemical Compounds in Food-Producing Animals: Criteria and Procedures for Evaluating Assays for Carcinogenic Residues, Federal Register 44, 17070–17114 March 20 1979) to establish procedures and minimum criteria to ensure the absence of cancer-causing residues in edible products of food ...
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Safety Assessment of Drug Residues

Journal of the American Veterinary Medical Association, 1980
SUMMARY The safety assessment of drug residues is part of the process for defining the conditions for the safe use of drugs in food-producing animals. The information needed to assess the safety of drug residues is provided by chemical and toxicity tests. Toxicity tests are conducted to identify the type of effect produced and to determine the exposure
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Assessing safety of agricultural chemicals

Canadian Journal of Physiology and Pharmacology, 1984
The objective of occupational health and safety programs in the chemical industry is to protect human health and the environment. Through studies in laboratory animals, bacteria, insects, and cultured cells, toxicologists collect data which allow them to predict which chemicals are likely to be hazardous to humans.
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A Safety-Critical Assessment Process

2014
Use of systems containing software is increasing rapidly in the safety-critical domain. It creates pressure to develop more rigorous process assessment methods for assessing systems and software development. The assessment process aims to ensure credibility and repeatability of assessment results.
Risto Nevalainen, Timo Varkoi
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Using human genetics to improve safety assessment of therapeutics

Nature Reviews Drug Discovery, 2022
Keren J Carss, Aimee M Deaton, Dorothee Diogo   +2 more
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