Results 101 to 110 of about 866,873 (340)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis and Identification of Requirements for a System to Enhance Situational Awareness at Sea [PDF]
TransNav, 2015 Pawel Banas +2 more
doaj +1 more source
Applications of GODAE Ocean Current Forecasts to Search and Rescue and Ship Routing [PDF]
Oceanography, 2009 As GODAE ocean forecast systems progress, their contributions toward improving the safety and efficiency of operations at sea will increase. In this article, we review present uses of GODAE ocean forecast systems for various safety applications at sea ...
Fraser J.M. Davidson +10 more
doaj
Swarm Intelligence Approach to Safe Ship Control
Polish Maritime Research, 2015 This paper presents an application of the Ant Colony Optimization (ACO) technique in a safe ship control system. The method developed solves the problem of path planning and collision avoidance of a ship in the open sea as well as in restricted waters ...
Lazarowska Agnieszka
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On Ship Systems Multi-state Safety Analysis [PDF]
TransNav, 2007 A multi-state approach to defining basic notions of the system safety analysis is proposed. A system safety function and a system risk function are defined.
Przemyslaw Dziula +3 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
HeliyonThis study aimed to clarify the effects of deep-sea pressure storage on the quality of whale meat, especially microbiological safety and physical properties, to examine the effectiveness of deep-sea storage for long-term aging of whale meat ...
Satomi Tsutsuura +4 more
doaj +1 more source
The Paris MOU on PSC, Propulsion and Auxiliary Machinery Deficiencies and the Maritime Safety [PDF]
TransNav, 2008 This article tries to show the relationship between one important set of deficiencies included in the Paris Memorandum of Understanding on Port State Control procedures, propulsion and auxiliary machinery, the importance of this set of deficiencies for ...
GermÁn de Melo Rodríguez, Ismael Cobos
doaj
Indo-Pacific offshore oil and gas safety and security: managing regional risks [PDF]
Key Points: Indo-Pacific offshore oil and gas exploration and exploitation activity is expanding massively in economically and strategically important, environmentally sensitive areas. The risks of offshore oil and gas safety and security
Lee Cordner
core