Results 1 to 10 of about 1,866,229 (342)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Health in Emergencies & Disasters Quarterly, 2022 Background: Safety plays a significant role in the oil & gas industries, where there are many risk factors that can cause accidents. This study aims to evaluate the level of safety culture among the employees of the operational units of South Zagros Oil &
Mohammad Reza Omidi +2 more
doaj
SWISS CHEESE IN BRAZIL: DISASTER CULTURE AND SAFETY CULTURE IN DISASTERS [PDF]
Ambiente & SociedadeThis article discusses points related to “disaster culture” and “safety culture” in Brazil, and debates how societal-structural factors influence the management of low incidence and high consequence disasters, such as dam breaks, which appear to provide ...
JEROEN WARNER +2 more
doaj +4 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Evaluation of Safety Culture among Healthcare Workers in Borujerd [PDF]
Muhandisī-i bihdāsht-i ḥirfah/ī, 2023 Background and Objective: A proper safety culture is one of the important factors that ensure a healthy and safe work environment. In order to ensure safety performance in the workplace, healthcare departments are required to establish safety rules and ...
Hamed Ahmadpour +3 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Leadership Style and Safety Culture in Commuter Railroads
SafetyPrevious research has repeatedly demonstrated the importance of both safety culture and leadership in promoting workplace safety. Several studies and reviews have identified transformational leadership style as an important contributor to a strong safety
Patrick Sherry
doaj +1 more source
Frontiers in Public Health, 2023 IntroductionImproving patient safety is one of the most critical components of modern healthcare. Emergency medical services (EMS) are, by nature, a challenging environment for ensuring patient safety.
Justyna Kosydar-Bochenek +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source