Results 161 to 170 of about 6,288,519 (257)

Artificial Intelligence Readiness in Clinical Trial Operations: A Narrative Review and Site-Level Governance Framework. [PDF]

Healthcare (Basel)
Wójcik S, Rulkiewicz A, Domienik-Karłowicz J.   +2 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Induced Pluripotent Stem Cells in Corneal Regeneration: Biological Progress, Translational Barriers and Clinical Outlook. [PDF]

Biomedicines
Al-Amarat TS, Mehta JS.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

The Bold Surgeon Syndrome: Contemporary Analysis of Overconfidence, Training Gaps, and Patient Safety in Plastic Surgery. [PDF]

Plast Reconstr Surg Glob Open
Cárdenas-Camarena L, Guerrero-García T, Lira-Alvarez M, Angulo-Ibarra T, Sosa-Durán J.   +4 more
europepmc   +1 more source

Evaluating and Predicting Maturity of Food Safety Culture in Food Manufacturing.

, 2017
Food safety culture might well be the most discussed item in modern food safety. As such, many offer opinions on what food safety culture is without offering science-based arguments and subsequently create more confusion than resolution. The research presented seeks to further the conversation through development of a valid and predictable system for ...
openaire   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Beyond burnout: occupational risk pathways linking stress, sleep, and multisystem morbidity in correctional officers. [PDF]

Front Public Health
Sun S, Xing P, Liu Y, Jia D.
europepmc   +1 more source

Safety culture maturity assessment for mining activities in South America

The final publication is available at IOS Press through http://dx.doi.org/10.3233/WOR-182781BACKGROUND:Health and safety is a crucial issue in the mining industry due to the implication of accidents in the sector.
Sanmiquel Pera, Lluís, Bascompta Massanes, Marc, Costa, M., Vintró Sanchez, Carla, Rossell Garriga, Josep Maria   +4 more
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