Results 201 to 210 of about 14,976 (239)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Examining the relationship between digital hospital level and patient safety culture: A study on healthcare workers. [PDF]

Digit Health
Avdan M, Aygün S, Tanış YE, Demir Uslu Y, Gökalp Y.   +4 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Innovative advances in microalgal high-value products: unlocking potential from bioprocessing to bioindustrial applications. [PDF]

Front Bioeng Biotechnol
Alqahtani A, Altoaimi B.
europepmc   +1 more source

Confidence Without Wisdom: The Dunning-Kruger Problem in Modern Surgery. [PDF]

Cureus
Moris D, Giorgakis E.
europepmc   +1 more source

From Concept to Practice: Lessons From the Balanced Nursing Teams Decision-Support System. [PDF]

JMIR Nurs
Vleminckx S, Van Bogaert P, De Keyser W, Haegdorens F.   +3 more
europepmc   +1 more source

Immature Honey as a Quality Challenge in Global Apicultural Production. [PDF]

Foods
Gajda A, Lewandowski B, Rujna P, Banach JK, Pietrzak-Fiećko R, Tkacz E.   +5 more
europepmc   +1 more source

Developing a maturity-level model for interprofessional collaboration in elective surgery preparation. [PDF]

Narra J
Agustina E, Dradjat RS, Wardhani V, Putra KR.   +3 more
europepmc   +1 more source

Engineering Stem Cells for Islet Replacement Therapy: Recent Advances and Barriers for Clinical Translation. [PDF]

Cells
Kuncha J, Veeraswamy SD, Darden CM, Kirkland J, Lawrence MC, Danobeitia JS, Naziruddin B.   +6 more
europepmc   +1 more source