Results 41 to 50 of about 212,913 (267)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Effects of the Driver’s Mental State and Passenger Compartment Conditions on Driving Performance and Driving Stress

Sensors, 2020
Globalization has increased the number of road trips and vehicles. The result has been an intensification of traffic accidents, which are becoming one of the most important causes of death worldwide.
Víctor Corcoba Magaña, Wilhelm Daniel Scherz, Ralf Seepold, Natividad Martínez Madrid, Xabiel García Pañeda, Roberto Garcia   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Understanding Electric Scooter Fall Accidents Through Human–Vehicle–Environment Interactions: A Systematic Literature Review Using the Haddon Matrix

Applied Sciences
This study aimed to investigate how human, vehicle, and environment (HVE)-related factors and their interactions contribute to fall accidents related to electric scooters (e-scooters). Falls are the most common type of e-scooter accidents, and developing
Clarista Josephine Nathania, Huiping Zhou, Tatsuru Daimon, Jieun Lee   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Narcolepsy, Driving and Traffic Safety

, 2008
Driving ability in narcolepsy patients is often affected due to excessive daytime sleepiness and disturbed vigilance. Cataplexy and sleep paralysis may also play a role, but to a lesser extent. In this chapter, epidemiological evidence and experimental studies assessing driving performance in narcolepsy patients are discussed.
Donjacour, Claire E H M, Mets, Monique A J, Verster, Joris C.   +2 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Narcolepsy, Driving and Traffic Safety

, 2016
Driving performance in narcolepsy patients is often affected. This is predominantly caused by excessive daytime sleepiness and disturbed vigilance. To a lesser extent cataplexy and sleep paralysis may play a role as well.This chapter discusses experimental studies assessing driving performance in both treated and untreated patients with narcolepsy ...
Donjacour, C.E.H.M., Mets, M.A.J., van de Loo, A.J.A.E., Verster, J.C.   +3 more
openaire   +2 more sources

On-Road Trajectory Planning of Connected and Automated Vehicles in Complex Traffic Settings: A Hierarchical Framework of Trajectory Refinement

IEEE Access
This paper presents a hierarchical framework for on-road trajectory planning in complex traffic environments. Firstly, the processing of sparse coarse trajectories involves the utilization of DP (Dynamic Programming) generation and interpolation ...
Fuzhou Zhao, Ling Han, Mingyang Cui, Heye Huang, Shan Zhong, Feifei Su, Lei Wang   +6 more
doaj   +1 more source