Results 51 to 60 of about 212,913 (267)

Analysis of the driving behavior when the system safety level during automated driving is presented to drivers

Mechanical Engineering Journal, 2019
In this study, it was analyzed how presenting information on the system safety level of automated driving system affects the driving behavior of driver, with the experiment using the driving simulator. During automated driving categorized to the level 2,
Keisuke SUZUKI, Kenta KAWATANI, Hiroki MORI, Yasuo SAKAGUCHI   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Real-Time Prediction of UAV Pilot Operational Errors and Adaptive Threshold Optimization Under Temporal Models

Journal of Advanced Transportation
Operational errors by UAV pilots have become a critical bottleneck constraining the safe development of the industry. Existing prediction methods mostly adopt unified models while neglecting the impact of individual pilot capability differences on error ...
Mengmeng Duan, Pengfei Feng, Huiqing Jin, Shulin Zhang, Mingyu Lu, Zhenghe Hu   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Glare Disability and Driving Safety

Ophthalmic Research, 2003
<i>Purpose:</i> Increasing investigation of the visual elements of safe driving environments may be of great benefit to society. Visual disability appears to be only one of many visual factors related to traffic accidents. The purpose of this article was to examine the type of visual impairment mediated by the increased glare sensitivity in
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

GCE3S:A Method for Generating Safety-critical Scenarios in Autonomous Driving Based on Evolutionary Search [PDF]

Jisuanji kexue
The rapid development of automated driving technology has brought great potential for transforming mobility,but automated driving technology,as safety-critical software,will lead to huge losses due to safety violations of self-driving vehicles in real ...
SUN Lele, HUANG Song, ZHENG Changyou, XIA Chunyan, YANG Zhen
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Investigating the driving skills-attitudes nexus for safer roads

IATSS Research
While current research extensively delves into the importance of driving skills and attitudes concerning traffic safety, a conspicuous gap remains in substantiating a meaningful correlation between self-reported driving skills and attitudes toward ...
Mahsa Bayat, Kayvan Aghabayk, Nirajan Shiwakoti   +2 more
doaj   +1 more source