Results 51 to 60 of about 1,174,768 (293)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Investigation of collision estimation with vehicle and pedestrian using CARLA simulation software

Journal of Mechanical Engineering and Sciences
The effectiveness of object detection systems in diverse driving environments is crucial in the growing field of automotive safety. The increasing frequency of traffic accidents, especially at busy intersections with heavy traffic and limited visibility,
Mohammad Sojon Beg, Muhammad Yusri Ismail   +1 more
doaj   +1 more source

Analysis of the driving behavior when the system safety level during automated driving is presented to drivers

Mechanical Engineering Journal, 2019
In this study, it was analyzed how presenting information on the system safety level of automated driving system affects the driving behavior of driver, with the experiment using the driving simulator. During automated driving categorized to the level 2,
Keisuke SUZUKI, Kenta KAWATANI, Hiroki MORI, Yasuo SAKAGUCHI   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Driver Safety Public Opinion Poll [PDF]

, 2017
The overall objective of this research is to provide the National Safety Council with an understanding of attitudes and behaviors of the driving public across a variety of driver safety-related issues.Results from this research will be used to develop ...

core  

Narcolepsy, Driving and Traffic Safety

, 2008
Driving ability in narcolepsy patients is often affected due to excessive daytime sleepiness and disturbed vigilance. Cataplexy and sleep paralysis may also play a role, but to a lesser extent. In this chapter, epidemiological evidence and experimental studies assessing driving performance in narcolepsy patients are discussed.
Donjacour, Claire E H M, Mets, Monique A J, Verster, Joris C.   +2 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Investigating the driving skills-attitudes nexus for safer roads

IATSS Research
While current research extensively delves into the importance of driving skills and attitudes concerning traffic safety, a conspicuous gap remains in substantiating a meaningful correlation between self-reported driving skills and attitudes toward ...
Mahsa Bayat, Kayvan Aghabayk, Nirajan Shiwakoti   +2 more
doaj   +1 more source