Results 61 to 70 of about 1,174,768 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On-Road Trajectory Planning of Connected and Automated Vehicles in Complex Traffic Settings: A Hierarchical Framework of Trajectory Refinement

open access: yesIEEE Access
This paper presents a hierarchical framework for on-road trajectory planning in complex traffic environments. Firstly, the processing of sparse coarse trajectories involves the utilization of DP (Dynamic Programming) generation and interpolation ...
Fuzhou Zhao   +6 more
doaj   +1 more source

Research and policy: Have we got the balance right? [PDF]

open access: yes, 2006
Since the shift towards reliance on evidence-led policies the amount and salience of road safety research commissioned by government and other public bodies has increased substantially.
Corbett, C
core  

Narcolepsy, Driving and Traffic Safety

open access: yes, 2016
Driving performance in narcolepsy patients is often affected. This is predominantly caused by excessive daytime sleepiness and disturbed vigilance. To a lesser extent cataplexy and sleep paralysis may play a role as well.This chapter discusses experimental studies assessing driving performance in both treated and untreated patients with narcolepsy ...
Donjacour, C.E.H.M.   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Effects of the Driver’s Mental State and Passenger Compartment Conditions on Driving Performance and Driving Stress

open access: yesSensors, 2020
Globalization has increased the number of road trips and vehicles. The result has been an intensification of traffic accidents, which are becoming one of the most important causes of death worldwide.
Víctor Corcoba Magaña   +5 more
doaj   +1 more source

Intelligent imaging system for optimal night time driving [PDF]

open access: yes, 2019
In the recent era, vehicles become a need of public. According to Statistic Portal, in year 2018 alone, more than 81 million vehicles were sold. This results in a large number of vehicles commuting on roads, thus increases the risks of road users.
Hui Ling, Chua, Huong, Audrey
core  

Glare Disability and Driving Safety

open access: yesOphthalmic Research, 2003
<i>Purpose:</i> Increasing investigation of the visual elements of safe driving environments may be of great benefit to society. Visual disability appears to be only one of many visual factors related to traffic accidents. The purpose of this article was to examine the type of visual impairment mediated by the increased glare sensitivity in
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

GCE3S:A Method for Generating Safety-critical Scenarios in Autonomous Driving Based on Evolutionary Search [PDF]

open access: yesJisuanji kexue
The rapid development of automated driving technology has brought great potential for transforming mobility,but automated driving technology,as safety-critical software,will lead to huge losses due to safety violations of self-driving vehicles in real ...
SUN Lele, HUANG Song, ZHENG Changyou, XIA Chunyan, YANG Zhen
doaj   +1 more source

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