Results 111 to 120 of about 7,316,150 (302)
Development of Statutory Methods for Calculation and Design of Tribo-Fatigue Systems. Part 1
Механика машин, механизмов и материалов, 2017 The article discusses briefly the principles that can be used as a basis for the development of normative methods for the calculation and design of Tribo-Fatigue systems.
Oleg M. Yelovoy +1 more
doaj
Design-Based Safety: The Evolution of Safety
, 2015 The word “safety” has a variety of meanings. It is a condition of being free from “accidents,” or any device for preventing an accident. The word “accident” means “unintended event,” and does not reveal that there is a cause created by a “hazard.” In ...
MacCollum, David
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
System Safety Bookshelf: Applying Safety Standards to Life-Saving Equipment
, 2019 Elsevier Academic Press has recently published a new safety book titled Safety Risk Management for Medical Devices, written by Bijan Elahi. This book explains how to conduct a risk management program that will show conformance to the FDA safety standards
Ericson, Clif
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
, 2014 In January 2013, a two-day Safety Case Workshop was conducted in Huntsville, Alabama under the sponsorship of the SAE International G-48 System Safety Committee and A-P-T Research, Inc. (APT). Attendees from industry, government and academia participated,
McDermid, John +7 more
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Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants
Annals of Clinical and Translational Neurology, EarlyView.Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold +12 more
wiley +1 more source
Strength and Deformation of Pillars during Mining in the Shaft Pillar
Applied SciencesThis study of the strength and deformation of coal samples was triggered by the need to define the stress–strain characteristics of pillars during room and pillar mining in the shaft protective pillar at the ČSM Mine.
Jindřich Šancer +3 more
doaj +1 more source
, 2008 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.v. 1, no. 2 (May 2008)-v. 2, no. 1 (Feb. 2009)Mode of access:
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