Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
A Guide for Traffic Safety Practitioners: Best Practices for Increasing Seat Belt Use in Rural Communities [PDF]
Rural motor vehicle occupants are at an increased risk for crash-related deaths compared to their urban counter-parts. One contributing factor is the lower use of seat belts in rural areas compared to urban areas. Seat belts are one of the most important
Thomas, F. D. +9 more
core
Water safety plan implementation in East Africa: Motivations and barriers [PDF]
, 2013 Water safety plans (WSPs) are a comprehensive source-to-tap risk management approach that are recognized as the most effective way of ensuring drinking water safety.
Parker, Alison, Summerill, Corinna
core +1 more source
LIFETIME OF AUXILIARY MACHINES OF AC ELECTRIC TRAINS
Nauka ta progres transportu, 2015 Purpose. In this paper it is necessary to analyze increase the efficiency of auxiliary machinesof AC electric trains, series ER 9M during operating under the real conditions. Methodology.
O. Yu. Baliichuk
doaj +1 more source
Solving the general 3-D safety factor by combining Sarma's idea with the assumption of normal stress distribution over the slip surface. [PDF]
PLoS One, 2023 Wang L, Lu K.
europepmc +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
Capability of safety climate to predict construction safety outcomes
, 2012 Safety climate refers to the degree to which employees believe that true priority is given to organizational safety performance. It is thought to be measured through a set of underlying factors such as management commitment.
Teo Ai Lin, Evelyn +5 more
core
Safety-factor dataset for high embankments determined with different analytical methods. [PDF]
Data Brief, 2021 Mesa-Lavista M +3 more
europepmc +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source