Results 101 to 110 of about 7,677,659 (304)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Multi-Source Monitoring and Numerical Simulation Deformation on Highway Steep Slopes Under Rainfall Effects

Buildings
Rainfall is one of the most important factors affecting slope stability. This study employed multi-source monitoring devices to observe the slope displacements in real time under rainfall infiltration and performed numerical simulations to investigate ...
Peijun Li, Qing Li, Qingshan Feng, Zhendong Huang, Xun Gan, Haibin Ding, Changjie Xu   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Motor vehicle safety defect recall campaigns.

, 1967
Mode of access: Internet.Continued by: Motor vehicle safety defect recall campaigns (Washington), ISSN 0565-7717, issued by: United States.
United States. National Highway Safety Bureau.
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Roles and Functions of Safety Professionals in Taiwan: Comparing the Perceptions of Safety Professionals and Safety Educators

, 2013
[[abstract]]Introduction The perspectives of both internal and external members have to be considered when developing safety curricula. This study discusses perceptional differences between safety educators (SEs) and safety professionals (SPs) regarding ...
Wu, Tsung-Chih
core  

Safety Case Workshop [PDF]

, 2014
In January 2013, a two-day Safety Case Workshop was conducted in Huntsville, Alabama under the sponsorship of the SAE International G-48 System Safety Committee and A-P-T Research, Inc. (APT). Attendees from industry, government and academia participated,
McDermid, John, Hendrix, Barry, Delong, Tom, West, Dave, Dezfuli, Homayoon, Swallom, Don, Frost, John, Schmedake, Robert   +7 more
core  

Development of Statutory Methods for Calculation and Design of Tribo-Fatigue Systems. Part 2

Механика машин, механизмов и материалов, 2018
The paper briefly discusses the principles that can be used as a basis for the development of statutory methods for calculating and designing of tribo-fatigue systems.
Oleg M. Yelovoy, Alexander V. Bogdanovich   +1 more
doaj  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source