Results 81 to 90 of about 7,316,150 (302)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Independence-Monmouth Traffic Safety Management Program (TSMP)
, 1981 Cover letter title: Independence-Monmouth Traffic Safety Management Program (TSMP).At head of title: Preliminary."July 1981.""OTSC Project #81-02-5-609."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents ...
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Impurity effects on kinetic ballooning instability in high regions of tokamak plasmas
Nuclear FusionThe impurity effects on kinetic ballooning modes (KBMs) in high $q$ regions of tokamak plasmas are numerically investigated, using a full gyrokinetic description for main and impurity ions. The findings indicate that the critical plasma pressure ratio ${\
J. Li +5 more
doaj +1 more source
Energies, 2018 The significant decreased wellbore temperature and increased casing pressure during fracturing fluid injection present a big challenge for the mechanical integrity of cement sheath in fracturing wells.
Honglin Xu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
LIFETIME OF AUXILIARY MACHINES OF AC ELECTRIC TRAINS
Nauka ta progres transportu, 2015 Purpose. In this paper it is necessary to analyze increase the efficiency of auxiliary machinesof AC electric trains, series ER 9M during operating under the real conditions. Methodology.
O. Yu. Baliichuk
doaj +1 more source
Human Factor in Functional Safety
Chemical Engineering Transactions, 2010 Abstract preview not available - see full-text PDF article.
openaire +2 more sources