Results 71 to 80 of about 1,108,809 (316)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Predicting Safety Culture: The Roles of Employer, Operations Manager and Safety Professional
, 2013 [[abstract]]Introduction: This study explores predictive factors in safety culture. Method: In 2008, a sample 939 employees was drawn from 22 departments of a telecoms firm in five regions in central Taiwan.
Wu, Tsung-Chih; Lin, Chia-Hung; Shiau, Sen-Yu
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Safety of betaine as a novel food pursuant to Regulation (EC) No 258/97 [PDF]
, 2017 Following a request from the European Commission, the EFSA Panelon Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on betaine as a novel food (NF) pursuant to Regulation (EC) No 258/97.
Heinonen, Marina +1 more
core +1 more source
Development and Validation of a Safety Leadership Self-Efficacy Scale (SLSES) in Maritime Context [PDF]
, 2020 Extensive studies have highlighted the importance of leadership on safety in the maritime industry. However, current research lacks empirically tested theoretical models with valid and reliable scales for describing and measuring safety leadership in ...
Sydnes, Are K. +4 more
core +1 more source
Frontiers in Veterinary ScienceStreptococcus agalactiae remains an important pathogen causing bovine mastitis, with measurable impacts on herd productivity and milk quality. Veterinary macrolides retain antibacterial activity against a substantial proportion of S. agalactiae isolates,
Huan Liu +23 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Safety procedures of coagulation factors [PDF]
Haemophilia, 2007 Abstract Two main types of safety procedures must be applied to biological products, including plasma derivatives: (i) preventive procedures and (ii) elimination procedures.Prevention includes epidemiological control of donor populations; checks on each donor’s health condition; analysis of each donation for the main pathogens using serological ...
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2013 [[abstract]]Introduction The perspectives of both internal and external members have to be considered when developing safety curricula. This study discusses perceptional differences between safety educators (SEs) and safety professionals (SPs) regarding ...
Wu, Tsung-Chih
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