Results 71 to 80 of about 7,677,659 (304)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Low-Cost Pedestrian Safety Zones: Countermeasure Selection Resource [PDF]

Contract DTNH2216D00017/TaskOrder 693JJ919F000174This project consists of two reports, this one and Low-Cost Pedestrian Safety Zones: Countermeasure Selection Resource. They were developed for State Highway Safety Offices and transportation professionals
University of North Carolina at Chapel Hill. Highway Safety Research Center, Dunlap and Associates, Inc., Center for Education and Research in Safety   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Low-Cost Pedestrian Safety Zones: An Eight-Step Handbook [PDF]

Contract DTNH2216D00017/TaskOrder 693JJ919F000174This project consists of two reports, this one and Low-Cost Pedestrian Safety Zones: Countermeasure Selection Resource. They were developed for State Highway Safety Offices and transportation professionals
University of North Carolina at Chapel Hill. Highway Safety Research Center, Dunlap and Associates, Inc., Center for Education and Research in Safety   +2 more
core  

Identifying NPP operator stressors using grounded theory

Scientific Reports
Nuclear power plant (NPP) operators manage crucial decision-making and operational tasks in precarious and complex environments, where psychological stress directly correlates with system safety and operational efficiency.
Ye Wang, Xiliang Tao, Wenqiang Peng, Zhaopeng Liu, Pengcheng Li   +4 more
doaj   +1 more source

Three-Dimensional Spectral Element Method Implementation for Evaluating Rooted Soil Behavior in Slope Stability Analysis

Geotechnics
Bioengineering techniques are being increasingly adopted as a sustainable solution to soil slope instability. Despite their recognized benefits, however, the mechanistic contribution of vegetation to slope stability remains inadequately understood due to
Ram Chandra Tiwari, Netra Prakash Bhandary   +1 more
doaj   +1 more source

Cardiac Factors of Safety [PDF]

Circulation Research, 1953
R S, ALEXANDER, C J, WIGGERS
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Investigation of Shear Strength Reduction Method in Slope Stability of Reinforced Slopes by Anchor and Nail

Buildings
Since the stability of slopes in infrastructures such as road and railroad embankments, excavations, and, in general, earthwork is important, analyzing the stability of these slopes has been one of the main focuses of geotechnical engineers.
SeyedSaber Hosseini, Farshad Astaraki, Seyed Mohammad Reza Imam, Jafar Chalabii, Majid Movahedi Rad   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source