Results 51 to 60 of about 1,108,809 (316)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ANALYSIS OF STRENGTH CHARACTERISTICS IN RAILROAD DOWELS PRODUCED BY VARIOUS MANUFACTURERS

Architecture and Engineering, 2019
The article describes operating conditions of the railroad dowel used in ZhBR 65 resilient rail fasteners. Requirements for railroad dowel tests in terms of their expediency, possibility to perform such tests and conformity with the actual operating ...
Dmitrii Nikitin, Liudmila Nikitina, Arthur Asoyan, Alexey Marusin   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The safety factor of a heterogeneous slope in an open-pit metal mine: A case study from the Tanjianshan gold mine

Frontiers in Earth Science, 2023
A landslide of the north open-pit (323N) and the stability and design optimization of the south open-pit (323S) slope in the 323 belts of the Tanjianshan Gold Mine were studied.
Xingdong Zhao, Yifan Zhao, Wenlong Yu
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Relationships between mental health and styles of help-seeking among care workers in comparison with the general population

Discover Mental Health
Background Care workers in long-term nursing homes often experience burdens and a high rate of resignations. This study aimed to investigate the mental health of care workers and to examine the relationship between the tendency to seek help and their ...
Tomoko Matsui, Hikaru Oba, Ryosuke Uchida, Tsukasa Teraguchi   +3 more
doaj   +1 more source

Significant factors affecting the effect of safety program implementation on construction projects in Ho Chi Minh City, Viet Nam

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2021
This research indicated 16 important factors that affect the result of labor safety program performance. The research was carried out by sending survey questionnaire to both foreigners and Vietnamese who are working for a medium and large scale ...
Dong Tam Vo Thanh Son
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Safety climate – cross-validation, strength and prediction of safety behaviour

, 2008
The present paper investigates the dimensionality of safety climate, tests a hypothesis of sharedness among members in a social unit as a characteristic of safety climate and tests the predictive validity of safety climate with regard to safety behaviour.
Pousette, Anders,, Törner, Marianne,, Larsson, Susanna,   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source