Results 31 to 40 of about 11,989,757 (288)

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Safety management within Task Force Uruzgan: A report of working with Unmanned Aerial Vehicles [PDF]

, 2013
In this paper we present a conceptualization of safety management that is based on the cybernetic concepts of “controllability” and “control capacity”. In particular, we explore what this conceptualization means for safety management of the Dutch Army’s ...
Moorkamp, Matthijs, Van Gulijk, C. (author), Kramer, Erik-Hans, Kramer, E.H. (author), Van Gulijk, Coen, Moorkamp, M. (author), Ale, B.J.M. (author), Ale, Ben   +7 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Experimental investigation into the Impact of Cyclic High Low Pressure Water Immersion on the Pore structure and Mechanical properties of coal

Scientific Reports
The extraction of coal seams with high gas content and low permeability presents significant challenges, particularly due to the extended period required for gas extraction to meet safety standards and the inherently low extraction efficiency.
Pi Zikun, Li Rui, Wang Yan, Xiong Jiawen, Li Jiayi, Zhang Yifu, Peng Bin   +6 more
doaj   +1 more source

Evaluation and obstacle analysis of high-quality development in Yellow River Basin and Yangtze River Economic Belt, China

Humanities & Social Sciences Communications, 2023
Based on China’s new development philosophy, and following the idea of “assessing the overall levels firstly, then anchoring the subsystems contributions and finally identifying the obstacle factors”, an evaluation system of high-quality development (HQD)
Xiaolin Yang, Zengwei Feng, Yiyan Chen
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evolution law of overlying rock fracture field in goaf mining with double-roof-cutting retaining roadway

Scientific Reports
This study comprehensively combines physical analog modeling, numerical simulation, on-site monitoring, and other methods to explore the overburden rock fissure development characteristics under double-roof-cutting (DRC) with retained roadway conditions.
Xiaobo Lv, Shengyong Hu, Jun Nian, Chunsheng Deng, Bo Zhao, Cheng He, Yansheng Wang, Xitu Zhang, Wei Zhang   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Gas migration control in goaf with double roof cutting and retaining roadway

Scientific Reports
The behavior of gas migration in goaf under double roof cutting conditions directly influences the effectiveness of gas control measures. This study employs a combination of numerical simulation and field verification to investigate the patterns of gas ...
Xiaobo Lv, Shengyong Hu, Jun Nian, Chunsheng Deng, Bo Zhao, Cheng He, Yansheng Wang, Xitu Zhang, Wei Zhang   +8 more
doaj   +1 more source