Results 51 to 60 of about 11,989,757 (288)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Independence-Monmouth Traffic Safety Management Program (TSMP)
, 1981 Cover letter title: Independence-Monmouth Traffic Safety Management Program (TSMP).At head of title: Preliminary."July 1981.""OTSC Project #81-02-5-609."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents ...
core
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Scientific ReportsThe competitive adsorption of CH4/CO2 in shale has consistently garnered significant attention as a means to enhance the recovery efficiency of shale gas reservoirs.
Yifu Zhang +5 more
doaj +1 more source
On the relation between culture, safety culture and safety management
, 2014 Safety can be considered an emergent phenomenon, making a systems view imperative if the aim is to evaluate or develop the safety of an entire sociotechnical system. This paper deals with one important component of the systems view - the relation between
Viitanen, Kaupo, +2 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
International Journal of Coal Science & TechnologyCoal is crucial to China’s economic and social development. The two primary factors hindering the high-quality development of China’s coal industry are safety and emissions.
Wenhao Deng +6 more
doaj +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Disaster-induced displacement in the Caribbean and the Pacific
Forced Migration Review, 2017 People in Small Island Developing States are particularly vulnerable to displacement by disaster. Governments in the Caribbean and the Pacific need urgently to do more risk management and planning, rather than focusing almost exclusively on response and ...
Mo Hamza, Ida Koch, Malte Plewa
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source