Results 61 to 70 of about 12,768,530 (407)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Decisions in safety management

Scientific Journal of the Military University of Land Forces, 2020
The article emphasizes that safety is the most important value for every person. Today, in the face of many threats, its level and interpretation are changing. The conditions of some phenomena also generate premises and possibilities for situations threatening health, life, environment, or infrastructure of a specific area to occur.
openaire   +3 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Experimental investigation into the Impact of Cyclic High Low Pressure Water Immersion on the Pore structure and Mechanical properties of coal

Scientific Reports
The extraction of coal seams with high gas content and low permeability presents significant challenges, particularly due to the extended period required for gas extraction to meet safety standards and the inherently low extraction efficiency.
Pi Zikun, Li Rui, Wang Yan, Xiong Jiawen, Li Jiayi, Zhang Yifu, Peng Bin   +6 more
doaj   +1 more source

The Investigation of Safety Management Systems and Safety Culture [PDF]

International Transport Forum Discussion Papers, 2017
Since every Safety Management System (SMS) is intended to provide a framework by which an organisation manages risk, it is inevitable that accident investigators will take a close interest. The good investigator will always want to understand how the SMS was intended to control risk and how this control failed when put to the test.
French, Simon, Steel, Tabitha
openaire   +3 more sources

Developing Key Safety Management Factors for Construction Projects in China: A Resilience Perspective

International Journal of Environmental Research and Public Health, 2020
It is acknowledged that construction safety is pivotal to the project management objectives. Meanwhile, the concept of resilience provides an effective and pragmatic countermeasure to improve the safety management level of construction projects. However,
Zheng Zhu, Jingfeng Yuan, Qiuhu Shao, Lei Zhang, Guangqi Wang, Xuewei Li   +5 more
semanticscholar   +1 more source

Risk management for traffic safety control [PDF]

, 2002
This paper offers a range of modelling ideas and techniques from mathematical statistics appropriate for analysing traffic accident data for the East region operation of CLP Power Hong Kong Limited and for the Hong Kong population in general.
Luczak, M.J., Wylie, J.
core  

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Gas migration control in goaf with double roof cutting and retaining roadway

Scientific Reports
The behavior of gas migration in goaf under double roof cutting conditions directly influences the effectiveness of gas control measures. This study employs a combination of numerical simulation and field verification to investigate the patterns of gas ...
Xiaobo Lv, Shengyong Hu, Jun Nian, Chunsheng Deng, Bo Zhao, Cheng He, Yansheng Wang, Xitu Zhang, Wei Zhang   +8 more
doaj   +1 more source

Numerical simulation on dust removal mechanism of magnetoelectric droplets and collision wetting coal dust

Meitan xuebao, 2023
In order to further improve the atomization and wetting performance of droplets, and increase the control efficiency of fine dust, in this study, the non-wetting anthracite dust in the Jincheng Mine was taken as an example.
Guangting XIONG, Shaocheng GE, Liying SUN, Xingyu PANG, Shuo LIU, Xi CHEN, Jun NIAN   +6 more
doaj   +1 more source