Results 61 to 70 of about 12,981,603 (362)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A simulation experiment study to examine the effects of noise on miners’ safety behavior in underground coal mines

BMC Public Health, 2021
Background Noise pollution in coal mines is of great concern. Personal injuries directly or indirectly related to noise occur from time to time. Its effects impact the health and safety of coal mine workers.
Jing Li, Yaru Qin, Lei Yang, Zhen Wang, Ke Han, Cheng Guan   +5 more
doaj   +1 more source

Finding Causal Paths between Safety Management System Factors and Accident Precursors

Journal of Management in Engineering, 2020
Understanding the causal relationships between safety management system (SMS) factors and accident precursors helps construction organizations identify which factors require improvement upo...
Estacio Pereira, Seungjun Ahn, SangUk Han, S. Abourizk   +3 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Experimental investigation into the Impact of Cyclic High Low Pressure Water Immersion on the Pore structure and Mechanical properties of coal

Scientific Reports
The extraction of coal seams with high gas content and low permeability presents significant challenges, particularly due to the extended period required for gas extraction to meet safety standards and the inherently low extraction efficiency.
Pi Zikun, Li Rui, Wang Yan, Xiong Jiawen, Li Jiayi, Zhang Yifu, Peng Bin   +6 more
doaj   +1 more source

Quality control and safety management of oil and gas pipelines during its whole life cycle

You-qi chuyun, 2023
The development history and technical change of oil and gas pipeline quality management in China were reviewed focusing on pipeline quality control in the whole life cycle, on the basis of quality improvement of oil and gas pipelines in the construction ...
Changliang JIANG
doaj   +1 more source

Risk management for traffic safety control [PDF]

, 2002
This paper offers a range of modelling ideas and techniques from mathematical statistics appropriate for analysing traffic accident data for the East region operation of CLP Power Hong Kong Limited and for the Hong Kong population in general.
Luczak, M.J., Wylie, J.
core  

Occupational safety and health practice: a study at quarry site by using hirarc form [PDF]

, 2020
Occupational Safety and Health Act (OSHA) is a discipline with wide scope involving many specialized fields. In other words, occupational health and safety comprises of aspects in terms of social, mental and physical.
Dhat run @ Chat run, Virakphon, Jaat, Norrizam, Khalid, Amir, Oh, Kar Heng, Tan, Jedidiah   +4 more
core   +1 more source

Developing Key Safety Management Factors for Construction Projects in China: A Resilience Perspective

International Journal of Environmental Research and Public Health, 2020
It is acknowledged that construction safety is pivotal to the project management objectives. Meanwhile, the concept of resilience provides an effective and pragmatic countermeasure to improve the safety management level of construction projects. However,
Zheng Zhu, Jingfeng Yuan, Qiuhu Shao, Lei Zhang, Guangqi Wang, Xuewei Li   +5 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source